Influence of related genetic polymorphisms to pharmacokinetics and pharmacodynamics of Fluvastatin

Abstract

Abstract: Fluvastatin is the first all chemical synthesis of cholesterol drugs. In the clinical treatment of the application of existing large differences.Muscle toxicity, liver toxicity,rhabdomyolysis is fluvastatin potential adverse reactions. In order to reduce the incidence of adverse reactions, so the lead to fluvastatin individual differences of the big reason has the great significance. This paper reviewes the CYP450 enzyme, drug transport body (OATP1B1, OATP1B3, OATP2B1, ABCG2) to fluvastatin pharmacokinetics characteristics of the influence and pharmacophore (CETP, ApoE) to fluoride polymorphisms of simvastatin pharmacodynamics characteristics influence. So as to ensure that the safety and efficacy of clinical medicine, and achieved the clinical personalized medicine.

Key words: Fluvastatin, Pharmacokinetics characteristics, Pharmacodynamics characteristics, Gene polymorphism

CLC Number:

R969

LIU Jing, XIONG Yu-qing. Influence of related genetic polymorphisms to pharmacokinetics and pharmacodynamics of Fluvastatin[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(11): 1282-1288.

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