Progress in uric acid transporters

Abstract

Abstract: Transport of uric acid by the kidneys rely on the transport protein in the renal tubular epithelial cells. Four kinds of urate transporters are involved in proximal tubular urate transport: human urate-anion exchanger 1(hURAT1) , which is responsible for the reabsorption of urate, human urate transporter (UAT) and organic anion transporter (OAT1 and OAT3),there are responsible for uric acid secretion. Recently, also found that the one responsible for uric acid secretion into the extracellular, involved in the renal proximal tubule reabsorption of urate transporter protein - glucose transporter protein (GLUT9). This article summarized the features, functions and regulatory mechanisms of uric acid transport protein.

Key words: Hyperuricemia, Uric acid transporters, Progress

CLC Number:

R589

ZHU Li-ran, CHEN Guang-liang. Progress in uric acid transporters[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(11): 1289-1294.

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