Apparent pharmacogenetics in antihypertensive therapy

Abstract

Abstract: With the development of pharmacogenetics,people gradually realize that gene polymorphism cannot fully explain the antihypertensive drugs curative effect of individual differences. At the molecular level,many antihypertensive drugs related metabolic enzyme,receptors,transporter are subject to the influence of the regulation of gene expression,and play an important role in differences of antihypertensive treatment. Therefore, from the perspective of epigenetics genetic factors and the relationship between the antihypertensive drugs,will help to better explain the clinical drug reaction from the individual differences. This review summarizes the DNA methylation,histone modification and microRNAs,apparent genetic control way for antihypertensive related drugs coding genetic effects.

Key words: Epigenetics, Pharmacogenetics, DNA methylation, Histone Modification, MicroRNAs, Hypertension

CLC Number:

R968

KUANG Ze-min, HUANG Zhi-jun, YANG Guo-ping, YUAN Hong. Apparent pharmacogenetics in antihypertensive therapy[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(3): 351-355.

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