Abstract: AIM: To research the effects of thyroxine replacement therapy in treating hypothyroidism.METHODS: Patients with primary hypothyroidism were collected and given levothyroxine sodium tablets for treating. Then thyroid function, heart function related indexes and blood lipids were detected 6 months later.RESULTS: After treatment, the levels of TSH, TG, TC, LDL, ApoB content and A peak were obviously lower than those before treatment(P＜0.05); the levels of FT3, FT4, HDL, ApoA-Ⅰ, E peak, E/A, LVEF, LVEDD were obviously higher than those before treatment(P＜0.05).CONCLUSION: Thyroxine replacement therapy which can effectively improve the thyroid, cardiac function and blood lipids has positive therapeutic significance.

Key words: Hypothyroidism, Thyroxine, Replacement therapy