Anti-inflammatory effects of carboxyamidotriazole on carrageenan-induced acute inflammation

Abstract

Abstract: AIM: To investigate the preventive effects of carboxyamidotriazole (CAI) in rat model of carrageenan-induced paw acute inflammation and its mechanisms.METHODS: The paw acute inflammation in rats was induced by carrageenan. The paw swelling was measured, and myeloperoxidase (MPO), NO, PGE₂, TNF-α, IL-1β, cytokine-induced neutrophil chemoattractant-1 (CNCI-1) and iNOS in the paw tissues were determined.RESULTS: CAI attenuated the carrageenan-induced paw swelling. CAI decreased the contents of MPO, NO, PGE₂, TNF-α, IL-1β and CNCI-1 in the inflamed paw tissues. Also, the protein expression of iNOS was reduced by CAI.CONCLUSION: CAI has anti-inflammatory effects against carrageenan-induced acute inflammation by decreasing the inflammatory mediators and the neutrophils infiltration.

Key words: Carboxyamidotriazole, Acute inflammation, Carrageenan, Myeloperoxidase, Inflammatory mediators

CLC Number:

R965.2

ZHU Lei, LI Juan, WU Dan-wei, YU Xiao-li, GUO Lei, YE Cai-ying, ZHANG De-chang. Anti-inflammatory effects of carboxyamidotriazole on carrageenan-induced acute inflammation[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(6): 601-605.

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