Table of Content

Volume 18 Issue 6
26 June 2013

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Anti-inflammatory effects of carboxyamidotriazole on carrageenan-induced acute inflammation

ZHU Lei, LI Juan, WU Dan-wei, YU Xiao-li, GUO Lei, YE Cai-ying, ZHANG De-chang

2013, 18(6):  601-605. 

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AIM: To investigate the preventive effects of carboxyamidotriazole (CAI) in rat model of carrageenan-induced paw acute inflammation and its mechanisms.METHODS: The paw acute inflammation in rats was induced by carrageenan. The paw swelling was measured, and myeloperoxidase (MPO), NO, PGE₂, TNF-α, IL-1β, cytokine-induced neutrophil chemoattractant-1 (CNCI-1) and iNOS in the paw tissues were determined.RESULTS: CAI attenuated the carrageenan-induced paw swelling. CAI decreased the contents of MPO, NO, PGE₂, TNF-α, IL-1β and CNCI-1 in the inflamed paw tissues. Also, the protein expression of iNOS was reduced by CAI.CONCLUSION: CAI has anti-inflammatory effects against carrageenan-induced acute inflammation by decreasing the inflammatory mediators and the neutrophils infiltration.

Cytotoxic activity of bortezomib against gastric cancer and its action mechanism

CHEN Hui, QU Li, HUANG Yong-gang

2013, 18(6):  606-609. 

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AIM: To study the cytotoxic activity of bortezomib against gastric cancer and its action mechanism.METHODS: MTT assay was used to detect the cytotoxic activity of bortezomib against gastric cancer SGC-7901 cells. The apoptosis were detected by Annexin V-FITC/PI staining and flow cytometry analysis. The protein expressions were determined by Western blot analysis.RESULTS: The IC₅₀ value of bortezomib against SGC-7901 cells was (54.6± 4.1) nmol/L. After treatment with 0, 50, and 100 nmol/L bortezomib for 48 h, the percents of apoptosis were (1.8±0.7)% ,(26.5±4.6)%,(41.7±5.8) % , respectively. There was significant difference among the different treatments(P<0.01). After treatment with 50 and 100 nmol/L bortezomib for 48 h, the cleaved-Parp and cleaved-caspase-3 were detected by Western blot analysis. After treatment with 50 and 100 nmol/L bortezomib for 48 h, the protein expression of Bmi-1 was downregulated.CONCLUSION: Bortezomib shows significant anticancer activity against gastric cancer SGC-7901 cells. The downregulation of Bmi-1 protein may played an important role in its apoptotic pathway.

Repair effect of human tissue kallikrein on sciatic nerve injury of rats

GENG Wu-jun , LIU Jun , TANG Hong-li, MO Yun-chang , WANG Dan-dan, WANG Jun-lu

2013, 18(6):  610-613. 

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AIM: To study the repair effect of human tissue kallikrein (HTK) on sciatic nervous of rats.METHODS: Thirty-six adult male SD rats weighted 180-220 g were randomly divided into 3 groups. The control group was just injected with 2 mL salt water by caudal vain every day. The SM group was injected with methylprednisolone 30 mg/kg(2 mL)by caudal vain every day. The HTK group was injected with human tissue kallikrein 17.5×10^-3 PNAU/kg (2 mL) by caudal vain every day. The sciatic functional index (SFI) at the day 1,3,5,7,9,11 and 13 after operation in all rats were calculated. The nerve conduction velocity of the sciatic nerve at the 14^th day postoperation was observed.RESULTS: All rats showed -100 at day 1 and 3. The HTK group and the SM group showed a statistically significant improvement over the control group from the 3^th day postoperation. The NCV of the HTK group and the SM group were greater than the control group (P<0.05).CONCLUSION: The repair effect of human tissue kallikrein (HTK) on sciatic nervous of rats was effective.

Protective effects of total flavonoids of Bidens bipinnata L on acute inflammation and possible mechanism

LIN Mei-ying, CHEN Fei-hu, GE Jin-fang, TANG Jie, NI Wen-lin

2013, 18(6):  614-620. 

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AIM: To investigate the protective effects of total flavones of Bidens bipinnata L (TFB) on acute inflammation and its possible mechanism.METHODS: Mice ear edema model was induced by dimethylbenzene, and ear edema degree was measured 30 min later. Adjuvant arthritis (AA) rats model was established through intradermal injected with freund's complete adjuvant, and paw swelling degree was observed. Serum TNF-α, IL-1, IL-6, IL-8, and IL-2 contents were detected through enzyme linked immunosorbent assay (ELISA) in both models. Histopathological changes of knee joint were measured through hematoxylin-eosin staining, and the protein expression of ASIC1a in cartilage tissue was tested through immunohistochemistry.RESULTS: Compared with that of the model group, the ear edema degree and serum TNF-α, IL-1, IL-6, and IL-8 contents in the TFB (100, 200 mg/kg) groups were decreased. Compared with that of the AA model rats, the paw swelling degree and the protein expression of ASIC1a in cartilage tissue were lower in TFB (67, 133 mg/kg) groups, while serum IL-2 contents were elevated. The histopathological changes in the knee joint of AA rats including the number of inflammatory cells could be ameliorated by TFB(33, 67, 133 mg/kg). Results of Person correlation test demonstrated that ASIC1a protein was positively correlated with serum TNF-α, IL-1 and IL-8 concentrations.CONCLUSION: TFB has protective effects on acute inflammation, the mechanism might be associated with inhibitting the release of inflammatory mediators.

Comparison of different inner diameter silver clip impact on 2K1C hypertension model

HUANG Ling-ling, YU Ting-ting, GUO Kun, LAN Chao-zong, LIU Biao, SONG Jia-zhi, LIU You-jing, WANG Xing-hui, GAO Shan

2013, 18(6):  621-626. 

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AIM: To compare the effect of three different inner diameter silver clips on 2K1C hypertensive rats.METHODS: A 2K1C hypertensive rats were established by narrow the right renal artery with different inner diameter of U-shaped silver clips. Animals were divided into 4 groups: the sham-operate group, 2K1C-0.2 mm group, 2K1C-0.25 mm group and 2K1C-0.3 mm group. The tail-cuff apparatus was employed to measure the rat tail arterial blood pressure during the 0-8 weeks. At the end of 8^th wk, the hemodynamics index recorded. The cardiac and kidney hypertrophy index were expressed as heart weight/body weight (HW/BW), left kidney weight/body weight (LKW/BW) and right kidney weight/body weight (RKW/BW). The aorta remodeling was investigated by HE stain. The content of hydroxyproline in myocardial tissue was measured by colorimetric determination. Radioimmunoassay method was used to detected the AngII content in serum.RESULTS: The 2K1C-0.25 group and 2K1C-0.3 group showed the higher model successful rate, less pyknotic kidneys, significant impairment of cardiac function, markedly increasing of HW/BW, vascular remodeling index, the content of hydroxyproline and the AngII content compared with sham-operate group. However, the 2K1C-0.2 group performed not well in model successful rate, pyknotic kidneys and the AngII content in serum.CONCLUSION: The 2K1C renovascular hypertension model that narrow the renal artery with 0.25 or 0.3 mm inner diameter of U-shaped silver clips proves to be the optimal one.

Effect of Ketotifen on pancreatic function of streptozotocin-induced type 2 diabetic rats

CHEN Zi-miao, CHEN Xiao-jun, WANG Mei-rong, PAN Liang-liang, HU Wan-li, NI Lian-song

2013, 18(6):  627-632. 

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AIM: To investigate the effect and mechanism of Ketotifen on pancreatic function of streptozotocin-induced type 2 diabetic rats.METHODS: Male SD rats were fed with high-carbon hydrate-fat diet 6 weeks and ip given STZ to induce a type 2 diabetes model. Rats of Ketotifen group were fed with Ketotifen 0.09 mg·kg^-1·d^-1, and killed in batches in different time (0, 4^th, 8^th week) to test the fasting blood glucose (FBG), fasting plasma insulin (FINS), the insulin sensitivity index (ISI) and homeostasis model assessment insulin resistance index (HOMA-IR) were calculated, the levels of Interleukin-6 (IL-6), tumor nectosis factor-alpha (TNF-α) were tested, and the pancreatic tissue were excised and observed by light microscope (LM) and transmission electron microscope, islet cell mitochondria were separated to test the activity of cytochrome C oxidase (CCO) and succinate dehydrogenase (SDH).RESULTS: Ketotifen suppressed serum glucose in diabetic rats (P<0.05), increased ISI and reduced HOMA-IR (P<0.01). Ketotifen reduced serum IL-6,TNF-α, increased the activity of CCO and SDH. Furthermore, Ketotifen can improve the morphological structure of islet cell.CONCLUSION: Ketotifen can improve the pancreatic function of streptozotocin-induced type 2 diabetic rats possibly by inhibition of activation of NF-κB to anti-inflammatory and improve the energy metabolism of βcell mitochondria.

Effect of sequoyitol on lipid metabolism in type 2 diabetic rats

CHEN Xiang-pan, YANG Jie-ren, LIU Yan, HAO Wei, LI Xian-wei

2013, 18(6):  633-637. 

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AIM: To observe the effects of sequoyitol on lipid metabolism in rats with type 2 diabetes.METHODS: Type 2 diabetic rats were induced by fed with a high fat and high sugar diet as well as injected with a low dosage of streptozotocin (35 mg/kg). Sequoyitol (12.5, 25, 50 mg·kg^-1·d^-1) was orally administered once a day in 35 model rats for 6 weeks. The contents of TG, TC, and low density lipoprotein cholesterol (LDL-C) were measured using fully automatic biochemical analyzer. ELISA was used to measure the contents of free fatty acids (FFA) in plasma,and the levels of apolipoprotein A₁ (Apo-A₁) and apolipoprotein B₁(Apo-B₁) in liver tissues. The content of leptin was measured with radioimmunoassay. In addition,pathological changes in liver was observed with MASSON staining.RESULTS: Sequoyitol reduced the contents of blood lipids,FFA,Apo-B₁ and leptin,elevated the content of Apo-A₁. At the same time,sequoyitol ameliorated hepatocellular fatty degeneration, reduced collagen deposition at liver cell interstitial and next to the blood vessels.CONCLUSION: The results show that sequoyitol regulates lipids metabolism and inhibites hepatic steatosis and collagen deposition in type 2 diabetes rats.

Expression and significance of TKTL1 in glioma

LI Shu, HONG Yun, ZHANG Gen-bao, YANG Shi-yong, ZHOU Yan-fang, TAO Bang-bao

2013, 18(6):  638-642. 

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AIM: To investigate the expression and significance of TKTL1 in glioma.METHODS: Fifty-four gliomas were collected immediately after surgery together with six normal brain tissues. The expression of TKTL1 in fifty-four gliomas and six normal pituitary tissues in terms of the mRNA and protein levels were detected by Realtime-PCR, Western blot and Immunohistochemistry analysis.RESULTS: The expression of TKTL1 in all glioma tissues was higher than that in normal brian tissues by wester blot and Realtime-PCR analysis (P<0.01), the expression amounts of protein and mRNA in high-grade gliomas and low-grade gliomas respectively were significantly different (P<0.01).CONCLUSION: The results reveal that the expression of TKTL1 is closely correlated with malignant degree of glioma, which indicates the expression of TKTL1 is intimately correlated with occurrence and development of glioma. Detecting TKTL1 may be a vital index to predict prognosis of glioma.

Effects of MDRl Gene C3435T polymorphism on bloold concentration and pharmacokinetics of telmisartan

CHENG Mao-liang, WANG Jue

2013, 18(6):  643-648. 

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AIM: To determine the effects of MDR1C3435T on the pharmacokinetics of telmisartan in healthy Chinese volunteers and blood concentration in hypertension patients.METHODS: The genotype on MDR1C3435T in 19 healthy Chinese volunteers who were received a single oral dose of 40 ng telmisartan and 61 hypertension patients who were received oral of 40 mg telmisartan every day after a month was detected by PCR RFLP method, the relationship of MDR1C3435T polymorphism and steady-state blood concentrations of telmisartan were determinated by HPLC-MS. The pharmacokinetics of telmisartan in health volunteers and steady-state telmisartan concentrations of patients with hypertension were compared among MDR1C3435T genotypes.RESULTS: Among the 61 cases of hypertension patients, the frequencies of C3435T CC, C3435T TT and C3435T CT were 39.34%, 11.48% and 49.18%, respectively. There were no differences between normal people and hypertension patients in MDR1 ditribution. No significant difference in C_max, t_max, t_1/2, AUC_0-48, AUC_0-∞ and CL among MDR1 C3435T genotypes in health volunteers and no significant difference in steady-state concentration among MDR1C3435T genotypes in hypertension patients were observed. CONCLUSION: The MDR1 C3435T polymorphism does not affect the blood concentration and pharmacokinetics of telmisartan.

Simple and sensitive HPLC method for determination of cefprozil in human plasma

WANG Yan-Jiao, YANG Rui, SHEN Jie, XIE Hai-tang, XIAO Jian

2013, 18(6):  649-653. 

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AIM: To establish the HPLC method for determination of cefprozil in plasma.METHODS: High-performance liquid chromatography with UV detection was used, Hypersil BDS C₁₈ (200 mm×4.6 mm, 5 μm) was the analysis column. The mobile phase was 20 mmol/L ammonium acetate/10% acetic acid(pH=3.7):acetonitrile=92∶8(V/V), the flow rate was 1.0 mL/min, the column temperature was 30 ℃, the detection wavelength was 282 nm,the injection volume was 20 μL.The plasma sample were directly precipitated with trifluoroacetic acid, the transfer supernatant was analyzed after centrifugation.RESULTS: Cefprozil was linear within 0.10-10.01 μg/mL(r=1.0000). The lowest quantitative concentration was 0.10 μg/mL.The RSD of intra-day or inter-day were less than 15%(n=15).CONCLUSION: The HPLC method is rapid, simple, convienient and effcient, and suitable for the determination of cefprozil in plasma.

Phase Ⅰ clinical trial design and the problems need to focus

QIAN Wei, XIAO Da-wei

2013, 18(6):  654-660. 

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Phase I clinical trials, especially the first in human trials (FIH) of drugs are with greatly challenging. There are many great progresses in design technology abroad. The starting dose, placebo-controlled, increasing doses, the trail termination criteria and risk assessment involved in the Phase I clinical trial were reviewed in this article.

Pharmacokinetics and intrapulmonary diffusion of levofloxacin in critically ill patients with severe community-acquired pneumonia

YE Ying

2013, 18(6):  661-668. 

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AIM: To compare the different medication regimens of levofloxacin in treatment of community-acquired pneumonia and provide evidence for clinical rational drug use.METHODS: Twenty-four adult patients with severe community-acquired pneumonia and receiving mechanical ventilation were assigned randomly into 2 groups (n=12) received 1-hour intravenous infusion of levotloxacin 500 mg once or twice daily respectively. The levotloxacin concentrations at steady-state in plasma and epithelial lining fluid were determined with high-performance liquid chromatography after 2 days of therapy. The pharmacokinetics was calculated and compared.RESULTS: Levotloxacin concentrations in plasma and epithelial lining fluid peak were (12.6±2.3) mg/L and (11.9±2.7) mg/L respectively in the once-daily group and(19.7±1.8) mg/L and(17.8±1.7)mg/L in the twice-daily group, showing pulmonary penetration percentage >100% in both groups. The total body exposure (AUC_24h)in the once-daily and twice-daily group was(151.2±12.8) mg·h·L^-1 and(208.6±15.1) mg·h·L^-1 respectively, each higher than the minimal inhibitory concentration for severe pneumonia. The treatment success rate in the once-daily and twice-daily group was 83%(10/12)and 92%(11/12)with no significant difference(P>0.05).CONCLUSION: For critically ill patients with severe community-acquired pneumonia and receiving mechanical ventilation, the administration of intravenous levofloxacin 500 mg once and twice daily all can reach the minimal inhibitory concentration.

Effect of Re-Du-Ning on outpatients with acute exacerbation of chronic obstructive pulmonary disease and influenza virus infection

LU Wen-xuan, HAN Wei, TANG Hua-ping, ZHANG Ming-yong

2013, 18(6):  669-673. 

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AIM: To evaluate the effect of Re-Du-Ning on airway oxidative stress and systemic inflammation of acute exacerbation of chronic obstructive pulmonary disease (COPD) with influenza virus infection.METHODS: 320 of COPD out-patients suspected with respiratory virus were enrolled from respiratory clinic successively. Respiratory syndrome, sputum and blood samples had been collected in the first morning after enrolled. After influenza virus in sputum was detected by RT-PCR, the patients with influenza virus were divided into 2 groups: Re-Du-Ning group, who received the treatment of Re-Du-Ning and control group, who received the treatment without Re-Du-Ning and other antioxidants.RESULTS: After treatment, BDI not MRC of Re-Du-Ning group was higher than control group with significant difference (P<0.05). MDA was lower in treatment group than in control group, so as IL-8, and the activity of SOD in treatment group was higher than that in control group (P<0.05).CONCLUSION: Re-Du-Ning improves the respiratory syndrome and systemic inflammation of chronic obstructive pulmonary disease with influenza virus infection via regulating of the imbalance of oxidative stress.

Long-term efficacy of intracoronary stem cells transplantation in patients with acute myocardial infarction

ZHU Lin-lin, XIE Xiang-rong, ZHANG Juan, SHAN Shou-jie , CHEN Shao-liang

2013, 18(6):  674-679. 

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AIM: To investigate the security as well as the improvement of cardiac function in patients with acute myocardial infarction who ac-cepted intracoronary transplantation of autologous bone marrow mesenchymal stem cells (MSCs),and to discuss the possible mechanism. METHODS: 20 cases of acute myocardial infarction patients after percutaneous coronary intervention (PCI) received intracoronary transplantation of MSCs. (treatment group). Another 20 patients who refused stem-cell therapy after PCI served as control (conrol group). All patients underwent clinical evaluation, 2D/TDI echocardiogram, and ¹⁸F-FDG-SPECT at 1 week/1 year after PCI.RESULTS: Body temperature elevation or malignant arrhythmia associated with transplantation was not found in treatment group. Compared with the control group, echocardiographic systolic and diastolic function parameters and SPECT metabolic defects indicators were improved significantly in treatment group 1 year after PCI,there were statistical differences(P<0.05).CONCLUSION: Intracoronary transplantation of MSCs is safe and effective, and may significantly improve long-term cardiac performance. MSCs-associated myocardial regeneration and neovascularization may be the possible mechanisms.

Analysis of the curative effect of idine-131 therapy for Graves disease and its influencing factors in Southern Anhui patients

GAO Jia-lin, XIA Li-bin, LU Mei-qin, ZHANG Bin-hua, CHEN Yue-pin, ZHANG An-su, ZHAO Yong-li, HUA Qiang, HE Chun-lin, TAO Shao-neng, YANG Ji-wen, XING Feng-jun, CHEN Guang-hua

2013, 18(6):  680-687. 

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AIM: To evaluate the therapeutic effect of ¹³¹I on patients with Graves disease, and analyze the influence factors of curative effect and the hypothyroidism occurrence.METHODS: The 398 patients had been retrospectively studied with definite diagnosis of Graves' disease within 2011 to 2012 after ¹³¹I treatment.RESULTS: Total curative rate was 46.7%, and the total effective rate was 86.7%. For the first time of treatment, the curative rate was 48.6%, and the effective rate was 87.3%. In most of the patients, the serum FT4 and FT3 were decreased in one to three months post ¹³¹I treatment. After statistical analyzing, 24 h ¹³¹I uptake rates, thyroid weight, dosage of ¹³¹I ,the number of treatment, were negative correlation with the curative rate, and with liver injury was also a impairing factors of therapy. Furthermore, in the numerous factors mentioned above, only 24 h ¹³¹I uptake rate has relationship with hypothyroidism occurrence in Single factor analysis way, which show as the lower iodine uptake rate with the higher incidence of hypothyroidism (χ²=7.487,P=0.02367);Multiple logistic regression analysis suggested that the gender, thyroid weight,the mumbers of treatment were significantly associated with the incidence of hypothyroidism.CONCLUSION: The curative effect of ¹³¹I therapy on Graves's disease was acceptable, and it can be used as the first choice of therapy for Graves's disease. However, individualized dosage should be used for the patients, because of the complex influence factors of therapeutic effects.

Clinical research of intensive dose atorvastatin on preventing contrast-induced nephropathy caused by high dose of contrast agent

CHEN Xiao-ying, ZOU Lin-lin

2013, 18(6):  688-691. 

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AIM: To investigate the effect of intensive dose atorvastatin in the use of iopamidol,a kind of low osmolar and non-ionic contrast agent,on renal function of patientsMETHODS: 200 patients who undergoing CAG and PCI were randomized to intensive dose atorvastatin group (80 mg 24 h before PCI,with a further 40 mg 2 h pre-procedure,n=100)or routine dose atorvastatin group (20 mg/d,n=100).All patients received intravenous saline hydration.And those who undergoing percutaneous PCI were divided into two groups according to different dosages of contrast agent :≤120 mL group and >120 mL group.The levels of Scr,BUN,and hsCRP were determined for the evidence of tubular or glomerular damage befour and after receiving diagnostic and therapeutic coronary intervention.Ccr was calculated according to Cockcroft-Gault formula.RESULTS: Compared with before operation,the values of Scr and BUN in two groups of patients were obviously higher after operation;but the value of Ccr was lower (P<0.05);the value of hsCRP was increased in routine dose atorvastatin group(P<0.05),the value of hsCRP was no change in intensive dose atorvastatin group(P>0.05).There was no significant difference in the values of renal function between ≤120 mL group and >120 mL group in intensive dose atorvastatin group.Compared with the >120 mL group,the values of the Scr,BUN,hsCRP were increased(P<0.05),the value of Ccr was decreased(P<0.05).The renal function had obvious diffenence in routine dose atorvastatin group between ≤120 mL group and >120 mL group. There were 12 patients with contrast-induced nephropathy (CIN)in routine dose atorvastatin group and the incidence of CIN was 12%;there were 8 patients with contrast-induced nephropathy (CIN)in>120 mL group,and the incidence of CIN was 14％.CONCLUSION: The use of intensive dose atorvastatin before angiography can reduce the effect of renal function induced by high dose of contrast agent and prevent the incidence of CIN.

Study on clinical efficacy of inhaled corticosteroids in the treatment of 94 children with cough variant asthma

LI Jing-jie, CHEN Xu-chen

2013, 18(6):  692-695. 

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AIM: To investigate the clinical values about budesonide of inhaled corticosteroids in the treatment of children with cough variant asthma.METHODS: The 94 cases of cough variant asthma children admitted to hospital from March 2007 to March 2011 were randomly divided into two groups, control group (n=47) and treatment group (n=47). The control group was treated with montelukast tablets and salbutamol aerosol, but the treatment group was also given budesonide dry powder inhaler. The clinical effects, the scores of asthma symptom, the time of cough symptom disappeared, and the level of lung function in 2 groups was observed and compared.RESULTS: The total effective rate in the treatment group was significantly higher than the control group (P<0.05); the symptom scores in the treatment group was significantly lower than the control group (P<0.05); the time of cough symptoms disappeared in the treatment group was significantly shorter than the control group (P<0.05); the index value of lung function in the treatment group were significantly better than the control group (P<0.05).CONCLUSION: There is a significant clinical efficacy about budesonide of inhaled corticosteroids for the treatment of children with cough variant asthma.

Role of Nrf2 in neuroprotection and its mechanisms

CAO Shan, ZHOU Gan, PENG Xiang-dong, YANG Guo-ping, ZHOU Hong-hao

2013, 18(6):  696-704. 

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Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor, which sensitive to the oxidative stress and electrophiles, translocation to nucleus after dissociation with Keap1, induce expression of a variety of cytoprotective and detoxification genes. Several of the genes which regulated by Nrf2 have been illustrated in prevention from neurodegenerative conditions. Work from several laboratories has implicated the potential for Nrf2-mediated transcription to protect conditions such as hypoxia, ischemic-reperfusion,Alzhemier's disease, Parkinson's disease and Amyotrophic lateral sclerosis, resulting from mechanisms involving oxidative stress. Nrf2 may be notable in fighting conditions with variable causes and etiologies. Therefore, we review the current literature that imply Nrf2 may be a crucial therapeutic target for neuronal system disease, as well as experiments that uncover potential mechanisms of protection.

Pathogenesis and treatment of the bone disease of multiple myeloma

HONG Juan, WANG Xin-hong

2013, 18(6):  705-709. 

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Multiple myeloma is a plasma cell malignancy and bone disease is one of the important clinical features.The mechanisms include the increase of bone resorption and the decrease of bone formation.The progress in acknowledge of the pathophysiology of myeloma bone disease leads to the development of new targeted drugs. This article summarizes the progression of the pathogenesis and treatment of multiple myeloma bone disease.

Study on the inhibition of glomerular mesangial cell proliferation

JING Xian, WANG Ya-qin, OUYANG Dong-sheng

2013, 18(6):  710-714. 

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The abnormal proliferation of mesangial cells is important in the inflammation process and the development process of glomerular disease. It is of great significance to control glomerular disease to clarify the mechanism of proliferation. The article reviewed newly progress in the mechanism and inhibitor of mesangial cell proliferation.

Molecular targeted therapy of colorectal cancer

SHENG Li-li, JI Zhao-ning

2013, 18(6):  715-720. 

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Colorectal cancer is one of the most common malignant tumors. For patients with metastatic colorectal cancer (mCRC), chemotherapy with fluoropyrimidines, oxaliplatin and irinotecan is the main treatment, but multi-drug resistance occurs very often. In recent years the successful development of targeted therapy improves survival in patients with mCRC. This article reviews the development of targeted agents for the treatment of mCRC.