Fenofibrate inhibits cardiac hypertrophy by up-regulation of short-chain acyl-CoA dehydrogenase

Abstract

Abstract: AIM: To investigate the effect of fenofibrate on the expression of short-chain acyl-CoA dehydrogenase (SCAD), cardiac lipid metabolism and cardiac hypertrophy in spontaneously hypertensive rats (SHR).METHODS: SHR were given fenofibrate for 8 weeks, then systolic pressure and the ratios of left ventricular weight to body weight, free fatty acid in blood serum and cardiac muscle were measured. The expression of PPARα and SCAD in myocardium were investigated by western blot. Enzyme activity of SCAD in myocardium was measured with the anaerobic electron transfer flavoprotein fluorescence reduction assay.RESULTS: Compared with WKY rats, systolic blood pressure and the ratios of left ventricular weight to body weight were markedly elevated in SHR. The expression of PPARα and SCAD in myocardium of SHR were decreased as compared with WKY group. The activity of SCAD in myocardium was lower than that in WKY rats. Free fatty acid in blood serum and cardiac muscle were higher than that in WKY rats. Compared with SHR, fenofibrate decreased the ratios of left ventricular weight to body weight, but had no effect on systolic blood pressure. After treated with fenofibrate, the expression of PPARα and SCAD in myocardium of SHR was increased in associated with lower contents of free fatty acid in blood serum and cardiac muscle.CONCLUSION: Fenofibrate may ameliorate cardiac hypertrophy by increasing the expression of SCAD and improving cardiac energy metabolism in SHR.

Key words: Fenofibrate, Cardiac hypertrophy, Peroxisome proliferators activated receptor, Short-chain acyl-CoA dehydrogenase, Fatty acid oxidation

CLC Number:

R965.2

ZHOU Si-gui, XU Li-peng, LU Yao, YUAN Xi, PAN Xue-diao, ZANG Lin-quan. Fenofibrate inhibits cardiac hypertrophy by up-regulation of short-chain acyl-CoA dehydrogenase[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(8): 868-873.

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