Abstract: AIM: To observe the effect of dexmedetomidine on intracranial aneurysms with stress response and awakening quality on tracheal extubation.METHODS: Select Hunt / Hess grading as I-II-class implementation of intracranial aneurysm surgery patients 50 cases, and randomly divided into dexmedetomidine group (group A) and normal saline group (group B), 25 patients in each. Group A were given dexmedetomidine with 0.5 μg/kg continuous infusion for 10 min before anesthesia, intraoperative 0.4 μg·kg^-1·h^-1 continuous infusion. Group B were given the same dose of 0.9% sodium chloride injection. Both groups were treated with combined intravenous-inhalation anesthesia. We recorded the changes of blood pressure (BP) and heart rate (HR) at into the operating room (T₁),extubation (T₂), extubation after 5 min (T₃), 10 min (T₄),measured the concentration of cortisol (COR), blood glucose (GLU), blood lactate (LAC), and recorded anesthesia recovery time,restlessness rating,visual analogue pain scores (VAS) and Ramsay sedation scores after extubation 30 min.RESULTS: The MBP, HR, COR, GLU, LAC of Group B increased more significantly (P<0.01 or P<0.05) than group A. Group B restlessness score and at VAS score 30 minutes after extubation were higher than those of group A, but Ramsay sedation scores were lower in group A (P<0.05).CONCLUSION: Dexmedetomidine can effectively inhibit the stress response to tracheal extubation period, can improve the quality of recovery from anesthesia, do not delay recovery.

Key words: Intracranial aneurysms, Tracheal extubation period, Stress response, Awakening quality, Dexmedetomidine