Function of pregnane X receptor in drug mechanism and research progress

Abstract

Abstract: Pregnane X receptor (PXR) is a member of the nuclear receptor superfamily NR1I subfamily, which is widely expressed in the liver and the intestine. The receptor as a key regulator of drug metabolism are widely involved in drug absorption, distribution, metabolism and excretion process.This review will introduce Ⅰ, Ⅱ phase metabolizing enzymes and transporters in the regulation of PXR. It will provide part of the basis for clinical drug interaction and drug research and development for PXR as a target.

Key words: Pregnane X receptor, Drug metabolism, Regulation

CLC Number:

R969

ZHANG Yi-wen, BAO Mei-hua, ZHOU Li-hua, ZHOU Hong-hao. Function of pregnane X receptor in drug mechanism and research progress[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(10): 1169-1174.

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