Advances in research on the mechanism of general anesthesia by specific manipulation of neuron activities

doi:10.12092/j.issn.1009-2501.2018.07.017

Abstract

Abstract:

Manipulation of the neuron activity is an important method in the research of general anesthetics. Traditional methods mainly involve electrical stimulation and local administrations of drugs into brain nuclei/lesion of nuclei, etc. have many shortcomings such as extended targets, poor spatial and time accuracy, and non-specific cell types. In recent years, novel strategies such as optogenetics and chemogenetics for controlling the activities of specific neurons were established, which are of high precisions on time and space scales, and of great significance to explore the retailed mechanisms of general anesthetics. This review summarized the principles and progresses of optogenetics and chemogenetics in the mechanism research of general anesthetics.

Key words: optogenetics, chemogenetics, general anesthesia, sleep-wake regulation, manipulation of specific neurons

CLC Number:

R964

XU Wei, QU Weimin, HONG Zongyuan. Advances in research on the mechanism of general anesthesia by specific manipulation of neuron activities[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(7): 825-829.

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