Abstract: AIM: To investigate the anti-inflammatory and immune regulation effect to asthma animal of oxygenase-1 (HO-1).METHODS: 60 Balb / C mice were randomly divided into control, model, Hemin, SnPP four groups. Blank group didn’t creat asthma model. Model group, Hemin group and SnPP mice were created asthma model by ovalbumin. Hemin group and SnPP group were given a certain amount of Hemin and SnPP, at the next day of the 27th day of administration, corresponding indicators were detected.RESULTS: After OVA sensitized excitation, compared with the control group,the OVA-SIgE concentration, BALF total cell number and EOS of model group were increased significantly (P<0.01), while Hemin group compared with model group had a very significant difference (P<0.01); levels of IL-10 in serum concentrations of model group compared with the control group decreased significantly (P<0.01),but Hemin group compared with the model group and SnPP group had increased in varying degrees; HO-1 expression of Model group, Hemin group and SnPP group was significantly increased compared with the control group; while Hemin group had increasd trend compared with SnPP group and model group.CONCLUSION: HO-1 may be inhibit airway inflammation of asthma mouse by promoting IL-10 factor, and can greatly reduce the serum levels of OVA-slgE and inflammatory cells. However, inflammation of asthma may be related to a variety of inflammatory cells and cytokines,it is a very complex process, and its anti-inflammatory mechanism of action requires further study.

Key words: HO-1, asthma, inflammation, immune