Recent progress in research and development of the impact of gene polymorphisms on thiopurine drugs

Abstract

Abstract: Gene polymorphisms affect the metabolisms of thiopurine drugs, which eventually become the main reason for the differences in efficacy and toxicity. Recently some researches have showed that there were no complete correlations between a single gene polymorphism of drug metabolizing enzyme or transporter and clinical adverse reactions of thiopurine drugs. However, the reasons of drug intolerance were probably more related to multi-genetic analyses. In this article, some of the recent developments of gene polymorphisms of several enzymes about thiopurine drugs were introduced. Meanwhile, the relationships between their metabolic characteristics and drug susceptibility were reviewed.

Key words: thiopurine, gene polymorphism, drug metabolizing enzyme, drug transporter

CLC Number:

R969.8

XIE Cai, YUE Li-jie. Recent progress in research and development of the impact of gene polymorphisms on thiopurine drugs[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(7): 818-823.

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