Advancement of antineoplastic activity research on heparanase drugs

Abstract

Abstract: Heparanase is a glucuronic acid enzyme, it hydrolizes heparin sulfate, which is main components of cell membrane and extracellular matrix, growth factors are released to promote tumor cell invasion and metastasis. As for the antineoplastic drug targets, a series of polysaccharides, synthetic small chemical compounds and natural product compounds have been found, some of them have begin the clinical research. The crystal structures of heparanase have successfully been discovered, so it is possible to do rational drug design based on 3D protein structures. This paper introduces antineoplastic activity research advance of heparanase inhibitors in details.

Key words: heparanase, protein structure, inhibitor, antineoplastic activity

CLC Number:

ZHANG Jun, CUI Ya-fang, ZHANG Chang-zhuo, ZHANG Ya, SHAO Peng. Advancement of antineoplastic activity research on heparanase drugs[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(8): 953-960.

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