Retrospective analysis of 119 cases with severe drug eruption

Abstract

Abstract: AIM: To investigate the common sensitize medicines and prevention of severe drug eruption and appreciate causal link between the drug and the reaction. METHODS: A retrospective study over a period of 7 years (January 2006 to December 2012) was carried out in the hospital to record severe cutaneous ADRs of 119 hospitalized patients.RESULTS: Antibacterials were the most common causative drugs(43,30.1%).Carbamazepine(32,26.9%) and allopurinol(23,19.3%) were the commonest initiating drugs.SJS accounted for the highest proportion,TEN accounted for the most dangerous.Two cases died of respiratory failure.CONCLUSION: Prone to cause severe drug eruption drug, strengthening pharmaceutical care during clinical use. abnormal timely withdrawal and giving sufficient corticosteroids treatment early to control the incidence of complications.

Key words: severe drug eruption, steven-johnson syndrome, toxic epidermal necrolysis, drug induced hypersensitivity syndrome, adverse drug reaction

CLC Number:

WANG Lin, QIU Xiao-yan. Retrospective analysis of 119 cases with severe drug eruption[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(8): 885-889.

References 17

[1]	章星琪. 药疹的发病机制研究和临床诊治进展-第二十二届世界皮肤科学大会内容介绍[J].皮肤性病诊疗学杂志,2011,18(5):351-352.
[2]	张学军. 皮肤病学[M] .6版.北京:人民卫生出版社,2005:113-114.
[3]	马川,李邻峰.45例重症药疹患者发病情况分析[J].中国麻风皮肤病杂志,2007,23(1):37-39 .
[4]	邱敏蕾,顾军.300例住院药疹患者临床特征分析[J]. 中国中西医结合皮肤性病学杂志, 2009, 8(5) : 271-273.
[5]	王芳,李毓,莫莹,等.药疹临床类型和致敏药谱最近七年与过去十年的对比变化[J].实用医学杂志,2011,27(21):3932-3934.
[6]	Huang HY,Luo XQ,Chan LS,et al.Cutaneous adverse drug reactions in a hospital-based Chinese population[J].Clin Exp Dermatol,2010,35(6):1-6.
[7]	何志新,甘戈,王宝玺.539例药疹临床分析[J].中华皮肤科杂志,2006,39(12):703-705.
[8]	Sushma M,Noel MV,Ritika MC,et al.Cutaneous adverse drug reactions:a 9-year study from a South Indian Hospital[J].Pharmacoepidemiol Drug Saf,2005,14(8):567-570.
[9]	Ozeki T,Mushiroda T,Yowang A,et al.Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population[J].Hum Mol Genet,2011,20(5):1034-1041.
[10]	Wu XT,Hu FY,An DM,et al.Association between carbamazepine-induced cutaneous adverse drug reactions and the HLA-B*1502 allele among patients in central China[J].Epilepsy Behav,2010,19(3):405-408.
[11]	罗婧莹,陈德华,黄熙,等.老年重症药疹33例临床分析[J].中国皮肤性病学杂志,2009,23(2):90-91.
[12]	Ozeki T,Mushiroda T,Yowang A,et al.Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population[J].Hum Mol Genet,2011,20(5):1034-1041.
[13]	Arndt C,Hawkins D,Anderson JR,et al.Age is a risk factor for chemotherapy - induced hepatopathy with vincristine,dactinomycin,and cyclophosphamide[J] .J Clin Oncol,2004,22(10):1894-1901.
[14]	李佳玟,郭毓文,王俐,等.重症药疹55 例临床分析[J].中国麻风病皮肤杂志,2004,20(4):356.
[15]	熊海祥. 42例重症药疹临床分析[J].皮肤病与性病,2012,34(1):34-35.
[16]	Huang HY,Luo XQ,Chan LS,et al.Cutaneous adverse drug reactions in a hospital-based Chinese population[J]. Clin Exp Dermatol,2011,36(2):135-141.
[17]	蔡泳,陈雪观. 别嘌醇致严重不良反应分析[J].医药导报,2012,31(2):264-266.