Protective effect of hydroxy safflower yellow A on myocardial ischemia

Abstract

Abstract: AIM: To investigate the protective effects of hydroxy safflower yellow A (HSYA) on myocardial ischemia. METHODS: Myocardial ischemia and blood stasis models were used to observe the effects of HSYA on myocardial ischemia, hemoreology changes and blood coagulatory function in rats. RESULTS: Myocardial ischemia experiment showed that HSYA could reduce the area of myocardial infarction, the level of serum CK-MB and LDH, and the blood viscosity and platelet aggregation had been reduced, while the values of PT and APTT had been prolonged. Blood stasis experiment showed that HSYA could reduce blood viscosity, inhibit platelet aggregation, and the values of PT and APTT had been prolonged. CONCLUSION: HSYA has protective effect on myocardial ischemia, the effect is related to improve hemorheology and blood coagulatory function.

Key words: hydroxy safflower yellow A, myocardial ischemia, blood stasis, hemorheology, blood coagulatory function

CLC Number:

R54
R965.2

DONG Wen-bin, YE Xiao-di, CHENG Min, WANG Jun-qing, ZHENG Gao-li. Protective effect of hydroxy safflower yellow A on myocardial ischemia[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(9): 1001-1005.

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