Abstract: AIM: To establish a mouse model with metabolic disorders similar to human metabolic syndrome (MetS) by induced with long-term 32% high sucrose-containing drinking water. METHODS: All male/female mice (3 weeks of age) were divided into two different groups randomly (n=10):control group and sucrose water (SW) group. Control group was received chow diet plus plain water, while SW group were received chow diet plus 32% sucrose water. At 24 weeks of age, oral glucose tolerance test (OGTT) were conducted to assess glucose handling ability of mice. Then, body weight, body length and waist circumference was measured in live mice, blood samples were collected from the orbital vein of experimental animals for measuring blood biochemical index. Then, mice were sacrificed and different parts of the adipose tissue were weighted and recorded. RESULTS: Compared with control mice, SW mice emerged a profound central obesity body characteristics. Based on the SW mice blood biochemical index examination, we found that SW mice have emerged glucose and lipid metabolism disorder. OGTT results suggest that: glucose processing capabilities of SW mice has shown a significant decline.For insulin metabolism, SW mice had significant hyperinsulinemia and insulin resistance.CONCLUSION: High sucrose water-induced MetS mice model well mimic the pathophysiological characteristics of MetS in humans. It is a readily available and low-cost animal model of MetS, and will provide a platform for the new therapeutic drugs of MetS.

Key words: metabolic syndrome, obesity, insulin resistance, hyperglycemia