ATP synthase beta subunit function and disease

doi:10.12092/j.issn.1009-2501.2018.04.017

Abstract

Abstract:

ATP synthase, also known as F1F0-ATP synthase, is the last link in the oxidative phosphorylation of respiratory chain in the mitochondrial membrane, chloroplast thylakoid membranes and photosynthetic bacteria membrane. The structure contains two subunits of F1 and F0, which are combined to decompose and synthesize ATP. ATP synthase beta subunit is an important component of F1F0-ATP synthase F1 subunit, which contains the catalytic sites needed for ATP synthesis and hydrolysis, and its function is directly related to the occurrence of disease. This article reviews the relationship between ATP synthase beta subunit and diabetes, tumor, obesity and other diseases.

Key words: ATP synthase beta subunit, rotational catalysis, diabetes, tumor, obesity

CLC Number:

R963

YUAN Lijialong, QIN Xuping. ATP synthase beta subunit function and disease[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(4): 464-470.

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