Abstract: AIM: To explore the therapeutic effect of compound Danshen dripping pills on chronic cerebral circulation insufficiency (CCCI) in patients with hypertension. METHODS: Fifty-two CCCI patients subjected to hypertension were randomly divided into Control and Test groups (n=26). All patients were received symptomatic treatment, and Test group was given compound Danshen dripping pills orally 3 times daily (10 pills/time) for 4 weeks. Clinlcal symptoms, cerebral arterial flow rate, and hemorheological index were determined. RESULTS: After 4 weeks of treatment, the dizziness, headache, dyssomnia and other CCCI symptoms in Test group were significantly reduced compared with Control group (P<0.05). The systolic blood flow rate (Vs) and diastolic blood flow rate (Vd) in left vertebral artery (LVA), basilar artery (BA), and right vertebral artery (RVA) were all markedly improved in Test group compared with pre-treatment and Control group (P<0.05). The hemorheological index in Test group also ameliorated compared with pre-treatment and Control group (P<0.05). CONCLUSION: Compound Danshen dripping pills is effective to treat CCCI in patients with hypertension and worthy of optimization and generalization.

Key words: compound Danshen dripping pills, hypertension, chronic cerebral circulation insufficiency, therapeutic effect