Epigenomic research progress on pathological mechanisms of intrahepatic cholangiocarcinoma

Abstract

Abstract: Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy with its molecular mechanism poor understood. It is prone to postoperative relapse and the response of chemotherapy on it is always disappointing. There is no available specific biomarkers for its early diagnosis. Recently, researchers have found that some genetic mutations, such as KRAS, EGFR, IDH1 and IDH2, gene methylation, miRNA and other epigenetic changes, abnormal activation of IL-6/STAT, tyrosine kinase receptors related signaling pathways are involved in ICC pathogenesis. Some of the key genes in it are becoming targets for molecular therapy. We are here to make a review on epigenomic research progress of ICC pathological mechanisms with the aim to promoting discovery of new biomarkers for its diagnosis and treatment, and to providing ideals for new strategy of medication in combination with molecular target drugs.

Key words: intrahepatic cholangiocarcinoma, epigeneomic, pathological mechanism, molecular target therapy

CLC Number:

R969.1

LIU Mou-ze, LI Hao, ZHANG Wei. Epigenomic research progress on pathological mechanisms of intrahepatic cholangiocarcinoma[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(11): 1294-1298.

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