Analysis of long-dated security and effectiveness for high-grade cervical intraepithelial neoplasia with loop electrosurgical excision procedure

Abstract

Abstract: AIM: To evaluate the security and effectiveness of loop electrosurgical excision procedure (LEEP) for high-grade cervical intraepithelial neoplasia(CINII,CINIII). METHODS: To analyze the clinical information of 87 patients whose pathology diagnosed as CINII,CINIII through LEEP in the First Affiliated Hospital of Wannan Medical College between January 2008 and December 2008 for 5 years and their disease outcome. RESULTS: During 5 years follow-up, 85 cases cured(97.7%) and 2 cases recurred(2.3%);Binary logistic regression analysis showed that age was the risk factor of recrudescence(P<0.05), but no significant relationship between gland involvement and recrudescence of CINII,CINIII after LEEP(P>0.05);5 patients who had no fertility history of preoperative owned natural conception.The conception rate was 100%.All of them had cesarean delivery(1 case/twice),without adverse pregnancy outcomes.5 cases received induced abortion, who did not have fertility desires pregnancy.1 case had missed abortion. CONCLUSION: LEEP is a secure and effectiveness treatment to CINII,CINIII and does not affect the pregnancy outcome.TCT combined with HPV test is a reliable method to postoperative follow-up.

Key words: cervical intraepithelial neoplasia, loop electrosurgical excision procedure, follow-up, pregnancy outcome

CLC Number:

R711

ZHANG Nan, HE Lian-zhi. Analysis of long-dated security and effectiveness for high-grade cervical intraepithelial neoplasia with loop electrosurgical excision procedure[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(12): 1411-1415.

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