Abstract: AIM: To investigate furosemide and ulinastatin's protective effects on renal function of patients with percutaneous nephrolithotomy. METHODS: 44 patients diagnosed as complicated renal calculi during January 2012 to February 2013 were selected and they all accepted percutaneous nephrolithotomy,then randomly divided into treatment group and control group,each group had 22 patients.In treatment group,the patients were subjected to the intravenous injection of furosemide(20 mg) and intravenous drip of ulinastatin(2×10⁵U) plus normal saline(100 mL) per day on preoperative day 1,intraoperative and postoperative day 1 to 3,and patients in control group only subjected to normal saline(100 mL).The levels of Cr,BUN,Urinary β₂-microglobulin and N-acetyl-β-glucosaminase of pelvic urine were measured post-intubation and first,third day after operation. RESULTS: Urinary β₂-microglobulin and N-acetyl-β-glucosaminase of first and third day after operation were significantly higher than those intraoperative in both groups(P<0.05),but the elevated extent in treatment group were smaller than control group(P<0.05);the levels of Cr,BUN of first and third day after operation were higher than those in control group. CONCLUSION: Furosemide and ulinastatin can play a certain role in protecting the renal function of patients with percutaneous nephrolithotomy.

Key words: furosemide, ulinastatin, percutaneous nephrolithotomy, renal function