Effect of remote ischemic preconditioning on the expression of myocardial ATP-sensitive potassium channel

Abstract

Abstract: AIM: To investigate the expression of sarcolemmal ATP-sensitive potassium channel in cardiomyocytes after remote ischemic preconditioning (RIPC).METHODS: Rat models of remote ischemic preconditioning were established by clipping bilateral femoral artery 5 minutes and opening 5 minutes for 3 cycles. Then, the expression of K_ATP channel in cardiomyocytes was evaluated in control group and groups at 1h, 4h, 24h and 48h postoperatively.RESULTS: The relative protein expression level of sarcolemmal ATP-sensitive potassium channel in cardiomyocytes was increased after RIPC.CONCLUSION: The expression of sarcolemmal ATP-sensitive potassium channel was increased after RIPC, the change of expression in ATP-sensitive potassium channel may play a role in the cardiac protection of RIPC against ischemia.

Key words: K_ATP channel, myocardial protection, ischemia reperfusion injury

CLC Number:

R965.2

XU Lin, ZHANG Deng-wen, YANG Shi-jie, TIAN Xue-bi, WANG Yu, HAN Ai-di, ZHANG Chuan-han, TIAN Yu-ke, WANG Xue-ren. Effect of remote ischemic preconditioning on the expression of myocardial ATP-sensitive potassium channel[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(4): 366-369.

References

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