The expression of high sensitive C-reactive protein and inflammation cytokines in periodontitis patients with hypertension and type 2 diabetes mellitus

Abstract

Abstract: AIM: To observe the levels of serum high sensitive C-reactive protein(hs-CRP), interleukin 1β(IL-1β), interleukin 6(IL-6) and tumor necrosis factors-α(TNF-α) in periodontitis patients with hypertension, type 2 diabetes mellitus and investigate the effect of hypertension, type 2 diabetes on the occurrence and development of periodontitis.METHODS: 140 patients from a hospital physical examination population (40 with only periodontitis, 35 with periodontitis and hypertension,40 with periodontitis and type 2 diabetes mellitus,25 with periodontitis and hypertension and type 2 diabetes mellitus ) were included in this study. Periodontal examinations,including periodontal probing depth(PD), attachment loss (AL), plaque index (PLI), bleeding index(BI) were recorded. The peripheral blood levels of hs-CRP,IL-1β,IL-6 and TNF-α were measured.RESULTS: The levels of PD,AL,PLI,BI in type 2 diabetes mellitus and hypertension complicated with periodontitis group were higher than those in periodontitis group,hypertension with periodontitis group and type 2 diabetes mellitus with periodontitis group (P<0.05). Those in hypertension complicated with periodontitis group , type 2 diabetes mellitus complicated with periodontitis group were higher than those in simple periodontitis group (P< 0.05).The levels of hs-CRP, IL-1β, IL-6 and TNF-α in type 2 diabetes mellitus and hypertension complicated with periodontitis group were higher than those in periodontitis group, hypertension with periodontitis group and type 2 diabetes mellitus with periodontitis group (P<0.05). Those in hypertension complicated with periodontitis group and type 2 diabetes mellitus complicated with periodontitis group were higher than simple periodontitis group (P<0.05).The levels of blood pressure and blood glucose in patients were the positive correlation with the levels of hs-CRP, IL-1β,IL-6 and TNF-α(P<0.01).CONCLUSION: The levels of hs-CRP, IL-1 beta, IL-6 and TNF-α in periodontitis patients with hypertension or type 2 diabetes mellitus, especially with type 2 diabetes mellitus and hypertension,were high, suggesting that hypertension complicated with type 2 diabetes mellitus may affect the occurrence and development of periodontitis.

Key words: periodontitis, hypertension, diabetes mellitus, high sensitive C-reactive protein, inflammatory cytokines

CLC Number:

R781.4

SHI Liu-xia, JIN Yue-long, WANG Xiang-yu, HE Lian-ping, YAO Ying-shui. The expression of high sensitive C-reactive protein and inflammation cytokines in periodontitis patients with hypertension and type 2 diabetes mellitus[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(5): 541-545.

References

[1] Tsakos G,Sabbah W,Hingorani AD,et a1.Is periodontal inflammation associated with raised blood pressure?Evidence from a National US survey[J].J Hypertens,2010,28(12):2386-2393.
[2] Etman MK,Woolford MJ.Three-year clinical evaluation of two ceramic crown systems: a preliminary study[J]. J Prosthet Dent, 2010,103(2):80-90.
[3] Borgnakke WS,Ylö ostalo PV,Taylor GW,et a1.Effect of periodontal disease on diabetes: systematic review of epidemiologic observational evidence[J].J Periodontol,2013,84(4 Suppl):S135-S152.
[4] 张津京,和璐.牙周炎对糖尿病影响的研究进展[J].北京口腔医学,2009,17(6):350-353.
[5] 郝柏杨,柴栋木,卢艳玲,等.原发性高血压的诊断[J].中外健康文摘,2012,33(1):52.
[6] 马学毅.现代糖尿病诊断治疗学[M].北京:人民军医出版社,2007: 25-26.
[7] Newman M,Takei H,Klokkevold PR.Carranza's Clinical Periodontology 10th ed[M].St.Louis:Saunders Elsevier Inc,2006:494-500.
[8] 王艳.牙周炎与高血压关系的研究进展[J].国际口腔医学杂志,2012,39(5):664-667.
[9] 郭晶,顾晓琪.糖尿病患者牙周病的相关性I临床分析[J].北华大学学报(自然科学版),2012,13(6):697-699.
[10]廖雁婷,和璐,李蓬,等.北京城区2型糖尿病患者牙周状况研究[J].中华糖尿病杂志,2010,2(4):248-252.
[11]朱莉,严丽英.社区糖尿病心血管病人群牙周状况调查[J].中西医结合心脑血管杂志,2008,6(9):118-120.
[12]欧晓丽,周嫣,陈燕,等.2型糖尿病患者口腔健康状况调查分析[J].广西医学,2013,35(12):1601-1603.
[13]王雷,赵斌,李红艳,等.牙周炎伴高血压患者牙周临床指标和血清抗心磷脂抗体水平的分析[J].牙体牙髓牙周病学杂志,2014,24(4):213-215,230.
[14]曹雪涛.医学免疫学[M].6版.北京:人民卫生出版社,2013:53-57.
[15]刘晓娟.超敏C反应蛋白与血脂检测在心脑血管疾病诊断中的应用[J].医学检验与临床,2011,22(6):104-105.
[16]梁建嫦.2型糖尿病合并冠心病患者hs-CRP和HbA1c测定的意义[J].吉林医学,2014,35 (7):1396-1397.
[17]Cottone S,Mule G,Nardi E,et al.Relation of C-reactive protein to oxidative stress and to endothelial activation in essential hypertension[J].Am J Hypertens,2006,19(3):313-318.
[18]Nakajima T,Honda T,Domon H,et al.Periodontitis-associated up-regulation of systemic inflammatory mediator level may increase the risk of coronary heart disease[J].J Periodontal Res, 2010,45(1):116-122.
[19]赵华,王小泉,赵红宇.2型糖尿病伴牙周炎患者牙周炎症程度与血糖水平分析[J].中华老年口腔医学杂志,2012,10(1):22-24.