Clinical observation of ERCC1 protein expression and cisplatin based chemotherapy on advanced esophageal cancer

Abstract

Abstract: AIM: To investigate the relationship between ERCC1 expression in advanced esophageal cancer and the chemotherapy effect treated with cisplatin.METHODS: 98 pathological specimens of advanced esophageal cancer patients were collected to detect ERCC1 expression. All patients received cisplatin chemotherapy The researchers observe the effect of patients receiving cisplatin-containing combination chemotherapy programs, and analyze the relationships between ERCC1 expression and objective response rate, disease control rate, progression-free survival, overall survival.RESULTS: In all 98 patients, the positive rate of ERCC1 expression was 56.1％(55/98), the overall disease control rate was 70.4％ (69/98), while objective response rate in negative group of ERCC 1 expression (76.7%) was higher than that in positive group (38.2%), which showed statistical difference (χ²=14.506, P=0.000); disease control rate in negative group of ERCC1 expression (88.4%) was higher than that in positive group (56.4%), which showed statistical difference (χ²=11.867, P=0.001). The expression of ERCC1 two groups progression-free survival and overall survival difference between positive and negative have similar changes (P＞0.05).CONCLUSION: The recent efficient of patients with ERCC1 negative expression in esophageal cancer pathological tissue is better than that of positive ERCC1 expression.

Key words: esophageal neoplasms, cisplatin, ERCC1

CLC Number:

R735.1

ZHANG Hong, GU Kang-sheng. Clinical observation of ERCC1 protein expression and cisplatin based chemotherapy on advanced esophageal cancer[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(5): 546-551.

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