双酚A与6月~2岁婴幼儿女童乳房发育的关系研究

doi:10.11852/zgetbjzz2014-22-11-09

中国儿童保健杂志 ›› 2014, Vol. 22 ›› Issue (11): 1147-1150.DOI: 10.11852/zgetbjzz2014-22-11-09

双酚A与6月~2岁婴幼儿女童乳房发育的关系研究

吴海瑛¹,陈临琪¹,何光照²,汪维鹏²,张学兰³

苏州大学1 附属儿童医院内分泌科;
2 药学院药物分析实验室;
3 附属儿童医院检验科,江苏苏州 215003

收稿日期:2014-04-10 发布日期:2014-11-10 出版日期:2014-11-10
通讯作者: 陈临琪,E-mail:clq631203@aliyun.com 注:^*苏州大学药学院研究生,现工作单位:江苏常州第四人民医院。
作者简介:吴海瑛(1979),女,上海人,主治医师,硕士学位,主要研究方向为儿童性发育。
基金资助:
苏州市科技局科技发展计划(应用基础研究)(SYS201242)

Corrlation research of bisphenol A and permature thelarche in infant girls aged 6 months to 2 years old

ZHANG Xue-lan³

1 Department of Endocrinology,Children's Hospital;
2 Pharmaceutical Analysis Laboratory College of Pharmaceutical Science Affiliated; 3 Clinical Lab,Children's Hospital Suzhou University,Suzhou,Jiangsu 215003,China)
Corresponding author:CHEN Lin-qi,Email:clq631203@aliyun.com

Received:2014-04-10 Online:2014-11-10 Published:2014-11-10
Contact: CHEN Lin-qi,E-mail:clq631203@aliyun.com

摘要/Abstract

摘要： 目的研究环境内分泌干扰物双酚A(bisphenol A,BPA)与2岁以下婴幼儿女童乳房发育(permature thelarche,PT)的关系。方法选择 6月~2岁PT 40例,正常同龄女童32例,利用高效液相色谱串联质谱法(HPLC-MS-MS)进行血清BPA 浓度测定,同时运用化学发光法进行血清性激素浓度:卵泡刺激素(follicule-stimulating hormone,FSH)、黄体生成素(luteinizing hormone,LH)、雌二醇(estradiol,E2)、泌乳素(prolactin,PRL)测定,比较两组差异及分析BPA与性激素之间相关性。结果 6月~2岁婴幼儿女童PT组血清BPA检出率及浓度均显著高于对照组(P均<0.01)。两组血清FSH,PRL浓度差异无统计学意义(P>0.05),PT组血清E2浓度高于对照组(P<0.05),PT组血清LH浓度高于对照组(P<0.01)。两组血清BPA浓度与FSH浓度、PRL浓度无相关性(P>0.05)。血清BPA浓度与E2和LH浓度有相关性(P<0.01)。结论 6月~2岁婴幼儿女童存在BPA的暴露;BPA暴露可能是6月~2岁婴幼儿女童出现PT的原因之一。6月~2岁婴幼儿女童BPA的暴露可能影响LH及E2的分泌。

关键词: 双酚A, 单纯乳房发育, 性激素

Abstract: Objective To investigate the association between bisphenol A (BPA) and permature thelarche in infant girls aged 6 months to 2 years old. Methods The blood samples were collected from 40 infants aged 6 months to 2 years old with PT and 32 normal femal infants.The concentration of BPA in serum was determine by using HPLC-MS-MS.The concentration of sex hormones follicule-stimulating hormone (FSH),luteinizing hormone (LH),estradiol (E2),prolactin (PRL) in serum were detected by chemiluminescence method at the same time.The difference between the two groups and the correlation between BPA and sex hormones were analysed. Results The relevance ratio and concentration of BPA in PT group were higher than those of the control group (P<0.01).The concentrations of FSH,PRL in the two groups had no statistically significant differences (P>0.05).The concentrations of E2 in PT group was higher than that of the control group (P<0.05).The concentrations of LH of PT group was higher than that of the control group (P<0.01).There were no correlation between the concentrations of BPA and FSH,PRL(P>0.05).There were correlations between the concentrations of BPA and LH,E2(P<0.01). Conclusions 6 months ~2 years old infant girls are under the existence of BPA exposure.BPA exposure is likely one of the causes of PT for 6 months ~2 years old infant girls.BPA exposure maybe affect the secretions of LH and E2.

Key words: bisphenol A, permature thelarche, gonadal hormone

中图分类号:

R725.8

吴海瑛,陈临琪,何光照,汪维鹏,张学兰. 双酚A与6月~2岁婴幼儿女童乳房发育的关系研究[J]. 中国儿童保健杂志, 2014, 22(11): 1147-1150.

ZHANG Xue-lan. Corrlation research of bisphenol A and permature thelarche in infant girls aged 6 months to 2 years old[J]. journal1, 2014, 22(11): 1147-1150.

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双酚A与6月~2岁婴幼儿女童乳房发育的关系研究

Corrlation research of bisphenol A and permature thelarche in infant girls aged 6 months to 2 years old

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