CC16基因多态性与儿童性哮喘相关性研究

doi:10.11852/zgetbjzz2016-24-02-14

中国儿童保健杂志 ›› 2016, Vol. 24 ›› Issue (2): 160-162.DOI: 10.11852/zgetbjzz2016-24-02-14

CC16基因多态性与儿童性哮喘相关性研究

马亚楠¹,朱运²,吕雪峰³,何钦成¹

1 中国医科大学公共卫生学院卫生统计教研室,辽宁沈阳 110122;
2 中国医科大学口腔医学院,辽宁沈阳 110001;
3 辽宁省大气污染防治管理中心,辽宁沈阳 110161

收稿日期:2015-04-08 发布日期:2016-02-01 出版日期:2016-02-01
通讯作者: 何钦成,E-mail:qche@mail.cmu.edu.cn
作者简介:马亚楠(1982-),男,讲师,博士学位,主要研究方向为环境流行病学。
基金资助:
国家自然科学基金(81302405);中华环境保护基金项目(CEPF2010-123-1-3);沈阳市科学技术项目计划项目(F13-220-9-34)

Received:2015-04-08 Online:2016-02-01 Published:2016-02-01

摘要/Abstract

摘要： 哮喘是一种常见的慢性呼吸系统疾病,特点是可逆性气流阻塞和气道高反应性,也是儿童呼吸系统常见病。本文对近年来Clara 细胞分泌蛋白(CC16)的基因38 A/G 多态性与儿童哮喘的相关性研究进行综述。

中图分类号:

R179

马亚楠,朱运,吕雪峰,何钦成. CC16基因多态性与儿童性哮喘相关性研究[J]. 中国儿童保健杂志, 2016, 24(2): 160-162.

[1] Shijubo N,Itoh Y,Yamaguchi T,et al.Serum levels of Clara cell 10-kDa protein are decreased in patients with asthma[J].Lung,1999,177(1):45-52.
[2] Van Vyve T,Chanez P,Bernard A,et al.Protein content in bronchoalveolar lavage fluid of patients with asthma and control subjects[J].Journal of Allergy and Clinical Immunology,1995,95(1):60-68.
[3] Sengler C,Heinzmann A,Jerkic SP,et al.Clara cell protein 16 (CC16) gene polymorphism influences the degree of airway responsiveness in asthmatic children[J].Journal of Allergy and Clinical Immunology,2003,111(3):515-519.
[4] Taniguchi N,Konno S,Hattori T,et al.The CC16 A38G polymorphism is associated with asymptomatic airway hyper-responsiveness and development of late-onset asthma[J].Annals of Allergy,Asthma & Immunology,2013,111(5):376-381.e1.
[5] de Torres JP,Campo A,Casanova C,et al.Gender and chronic obstructive pulmonary disease in high-risk smokers[J].Respiration;International Review of Thoracic Diseases,2005,73(3):306-310.
[6] Thomas NS,Holgate ST.Genes for asthma on chromosome 11:an update[J].Clinical and experimental allergy:Journal of the British Society for Allergy and Clinical Immunology,1998,28(4):387-391.
[7] Lee HK,Hsu AK,Sajdak J,et al.Coexpression analysis of human genes across many microarray data sets[J].Genome Research,2004,14(6):1085-1094.
[8] Mao XQ,Shirakawa T,Kawai M,et al.Association between asthma and an intragenic variant of CC16 on chromosome 11q13[J].Clinical Genetics,1998,53(1):54-56.
[9] Pedersen SE,Hurd SS,Lemanske RF,et al.Global strategy for the diagnosis and management of asthma in children 5 years and younger[J].Pediatric Pulmonology,2011,46(1):1-17.
[10] Martinez FD.Genes,environments,development and asthma:a reappraisal[J].European Respiratory Journal,2007,29(1):179-184.
[11] Shijubo N,Itoh Y,Yamaguchi T,et al.Clara cell protein-positive epithelial cells are reduced in small airways of asthmatics[J].American Journal of Respiratory and Critical Care Medicine,1999,160(3):930-933.
[12] 王秀芳,侯颖莹,毕丹.Clara 细胞分泌蛋白 10 在 5 岁以下喘息儿童外周血中的表达[J].中国当代儿科杂志,2011,13(3):199-201.
[13] Calvo FQ,Fillet M,De Seny D,et al.Biomarker discovery in asthma‐related inflammation and remodeling[J].Proteomics,2009,9(8):2163-2170.
[14] Shijubo N,Itoh Y,Yamaguchi T,et al.Development of an enzyme-linked immunosorbent assay for clara cell 10-kDa Protein:in pursuit of clinical significance of sera in patients with asthma and sarcoidosis[J].Annals of the New York Academy of Sciences,2000,923(1):268-279.
[15] Dierynck I,Bernard A,Roels H,et al.The human Clara cell protein:biochemical and biological characterisation of a natural immunosuppressor[J].Multiple Sclerosis,1996,1(6):385-387.
[16] Hayward A.Who's to blame for asthma?[J].The Lancet,1995,346(8985):1243.
[17] Johnston CJ,Mango GW,Finkelstein JN,et al.Altered pulmonary response to hyperoxia in Clara cell secretory protein deficient mice[J].American Journal of Respiratory Cell and Molecular Biology,1997,17(2):147-155.
[18] Drazen JM,Israel E,O'Byrne PM.Treatment of asthma with drugs modifying the leukotriene pathway[J].New England Journal of Medicine,1999,340(3):197-206.
[19] Bakhu M,Graves PE,Erikson RP.Lack of association between a polymorphism of the CC16 gene and increased susceptibility to asthma[J].Am J Pespir Cri Care Med,1998,157:A771.
[20] Laing IA,Goldblatt J,Eber E,et al.A polymorphism of the CC16 gene is associated with an increased risk of asthma[J].Journal of Medical Genetics,1998,35(6):463-467.
[21] Sengler C,Heinzmann A,Jerkic SP,et al.Clara cell protein 16 (CC16) gene polymorphism influences the degree of airway responsiveness in asthmatic children[J].Journal of Allergy and Clinical Immunology,2003,111(3):515-519.
[22] Ohchi T,Shijubo N,Kawabata I,et al.Polymorphism of Clara cell 10-kD protein gene of sarcoidosis[J].American Journal of Respiratory and Critical Care Medicine,2004,169(2):180-186.
[23] Chen LC,Tseng HM,Wu CJ,et al.Evaluation of a common variant of the gene encoding clara cell 10 kd protein (CC10) as a candidate determinant for asthma severity and steroid responsiveness among Chinese children[J].Journal of Asthma,2012,49(7):665-672.
[24] Ku MS,Sun HL,Lu KH,et al.The CC16 A38G polymorphism is associated with the development of asthma in children with allergic rhinitis[J].Clinical & Experimental Allergy,2011,41(6):794-800.
[25] Gao PS,Mao XQ,Kawai M,et al.Negative association between asthma and variants of CC16 (CC10) on chromosome 11q13 in British and Japanese Populations[J].Human Genetics,1998,103(1):57-59.
[26] Bakhu M,Graves PE,Erikson R P.Lack of association between a polymorphism of the CC16 gene and increased susceptibility to asthma[J].Am J Pespir Cri Care Med,1998,157:A771.
[27] 桂芹,钱桂生,黄挂君,等.CCl6 基因 G38A 突变与汉族哮喘相关性的研究[J].中华医学遗传学杂志,2004,20(6):542-543.
[28] Sharma S,Ghosh B.Association of an intragenic microsatellite marker in the CC16 gene with asthma in the Indian population[J].Journal of Human Genetics,2004,49(12):677-683.

CC16基因多态性与儿童性哮喘相关性研究

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