新生儿维生素D与血浆胰岛素及血糖水平的相关性研究

doi:10.11852/zgetbjzz2016-24-05-07

中国儿童保健杂志 ›› 2016, Vol. 24 ›› Issue (5): 469-471.DOI: 10.11852/zgetbjzz2016-24-05-07

新生儿维生素D与血浆胰岛素及血糖水平的相关性研究

王爱萍,李杨方,柴琳,吴玉芹,陶娜,杨汝文,赵晓芬,邱丽玲

昆明市儿童医院,云南昆明 650228

收稿日期:2015-07-07 发布日期:2016-05-10 出版日期:2016-05-10
作者简介:王爱萍(1978-),女,副主任医师,硕士研究生导师,研究方向为早产儿疾病的诊治及保健。
基金资助:
昆明市2012年科技计划项目(2012-04-01-A-S-02-1014)

Correlation between vitamin D with fasting plasma insulin and blood glucose in neonates.

WANG Ai-ping,LI Yang-fang,CHAI Lin,WU Yu-qin,TAO Na,YANG Ru-wen,ZHAO Xiao-fen,QIU Li-ling.

Kunming Children's Hospital,Kunming,Yunnan 650228,China

Received:2015-07-07 Online:2016-05-10 Published:2016-05-10

摘要/Abstract

摘要： 目的研究新生儿血清维生素D(VitD)是否与空腹血浆胰岛素(INS)、C肽(CP)及血糖(GLU)水平之间存在相关性。方法选取100例新生儿作为研究对象(其中足月儿58例,早产儿42例),检测血清25-羟基维生素D₂[25(OH)D₂]、血清25-羟基维生素D₃[25(OH)D₃]、血清25-羟基维生素D[25(OH)D]、空腹血浆胰岛素(INS)、C肽(CP)及血糖(GLU)浓度,采用SPSS 17.0对数据进行独立样本t检验和Pearson相关分析。结果足月儿组血清25(OH)D₃、25(OH)D、空腹血浆INS、CP、空腹GLU浓度高于早产儿组,差异有统计学意义(P＜0.05)。足月儿血清25(OH)D₃、25(OH)D与空腹血浆INS、CP呈正相关(r=0.515,0.324,0.523,0.335,P＜0.05或<0.01),与空腹GLU呈负相关(r=-0.489,-0.514,P均＜0.01)。早产儿血清25(OH)D₃、25(OH)D与空腹血浆INS、CP呈正相关(r=0.509,0.367,0.598,0.432,P<0.05或＜0.01),与空腹GLU呈负相关(r=-0.539,-0.587,P均＜0.01)。结论新生儿期血清VitD与空腹血浆INS、CP呈正相关,与空腹血糖呈负相关。

关键词: 新生儿, 足月儿, 早产儿, 维生素D, 胰岛素, C肽, 血糖

Abstract: Objective To explore correlation between vitamin D with fasting plasma insulin,C-Peptide and blood glucose. Method The concentrations of serum 25-hydroxyvitamin D₂[25(OH)D₂],25-hydroxycholecalciferol[25(OH)D₃],25-hydroxyvitamin D[25(OH)D],fasting plasma insulin(INS),C-Peptide(CP)and blood glucose (GLU) were measured in 58 full-term infants and 42 preterm infants,and the data were statistically analyzed by SPSS 17.0 software. Results The 25(OH)D₃,25(OH)D,INS,CP and GLU in group of full-term infants were higher than those in group of preterm infants(P<0.05).Levels of serum 25(OH)D₃,25(OH)D in full-term infants had positive correlations with INS,CP (r=0.515,0.324,0.523,0.335,P＜0.05 or <0.01),and negative correlations with GLU(r=-0.489,-0.514,all P＜0.01).Levels of serum 25(OH)D₃,25(OH)D in preterm infants had positive correlations with INS,CP (r=0.509,0.367,0.598,0.432,P<0.05 or ＜0.01),and negative correlations with GLU(r=-0.539,-0.587,all P＜0.01). Conclusion Levels of serum 25-hydroxyvitamin D in neonates have positive correlations with fasting plasma insulin and C-Peptide,and negative correlations with blood glucose.

Key words: neonate, full-term infant, preterm infant, vitamin D, insulin, C-Peptide, blood glucose

中图分类号:

R179

王爱萍,李杨方,柴琳,吴玉芹,陶娜,杨汝文,赵晓芬,邱丽玲. 新生儿维生素D与血浆胰岛素及血糖水平的相关性研究[J]. 中国儿童保健杂志, 2016, 24(5): 469-471.

WANG Ai-ping,LI Yang-fang,CHAI Lin,WU Yu-qin,TAO Na,YANG Ru-wen,ZHAO Xiao-fen,QIU Li-ling.. Correlation between vitamin D with fasting plasma insulin and blood glucose in neonates.[J]. journal1, 2016, 24(5): 469-471.

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新生儿维生素D与血浆胰岛素及血糖水平的相关性研究

Correlation between vitamin D with fasting plasma insulin and blood glucose in neonates.

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