淋巴毒素α基因rs1800683 G>A位点多态性与川崎病的关联性研究

doi:10.11852/zgetbjzz2016-24-05-08

中国儿童保健杂志 ›› 2016, Vol. 24 ›› Issue (5): 472-474.DOI: 10.11852/zgetbjzz2016-24-05-08

淋巴毒素α基因rs1800683 G>A位点多态性与川崎病的关联性研究

曾才秀¹,詹霞²,周进¹,谢圭²,袁海斌¹,周钗¹,杨作成²

1 湖南省湘潭市妇幼保健院儿科,湖南湘潭 411100;
2 中南大学湘雅三医院儿科,湖南长沙 410013

收稿日期:2015-10-13 发布日期:2016-05-10 出版日期:2016-05-10
通讯作者: 杨作成:E-mail:yang_zcr@126.com
作者简介:曾才秀(1957-),女,湖南人,主任医师,学士学位,主要研究方向为心血管及免疫性疾病。
基金资助:
湘潭市科技局科研基金(SF20142002)

Association of locus rs1800683 G>A polymorphisms of lymphotoxin-alpha gene with Kawasaki disease.

ZENG Cai-xiu¹,ZHAN Xia²,ZHOU Jin¹,XIE Gui²,YUAN Hai-bin¹,ZHOU Chai¹,YANG Zuo-cheng².

1 Maternal and Child Health Care Hospital of Xiangtan City,Xiangtan,Hunan 411100,China;
2 Department of Pediatrics,The Third Xiangya Hospital of Central South University,Changsha,Hunan 410013,China

Received:2015-10-13 Online:2016-05-10 Published:2016-05-10
Contact: YANG Zuo-cheng,E-mail:yang_zcr@126.com

摘要/Abstract

摘要： 目的通过检测淋巴毒素α(LTA)基因rs1800683 G>A位点多态性,探讨淋巴毒素α基因rs1800683 G>A位点多态性与川崎病(KD)发病及KD冠脉损伤的关联性。方法应用基因测序方法,对100例KD组与92例健康对照组儿童淋巴毒素α基因rs1800683 G>A位点多态性进行基因检测;结果 KD组的淋巴毒素α基因rs1800683 G>A位点AG、AA、GG基因型分布和A、G等位基因频率与健康对照组比较差异无统计学意义(χ²=3.78和2.84,P均>0.05),KD组的合并CAL组与NCAL组基因型和等位基因频率比较差异亦无统计学意义(χ²=3.76和0.43,P均>0.05)。结论未发现淋巴毒素α基因rs1800683 G>A位点多态性与KD的发病及其冠脉损伤存在明显关联性。

关键词: 淋巴毒素α基因, 基因多态性, 川崎病

Abstract: Objective To investigate the relationship between the locus rs1800683 G>A polymorphisms of lymphotoxin-alpha (LTA) gene with Kawasaki disease (KD). Method The Sanger gene sequencing method was employed to detect the genotype of locus rs1800683 G>A polymorphisms of LTA gene in 100 patients with KD and 92 healthy controls. Results For locus rs1800683 G>A polymorphism in LTA gene,there was no significant difference between the KD and healthy controls in genotyping frequencies of AG,AA and GG respectively (χ²=3.78,P>0.05),and there was no significant difference in the allele frequencies of A and G between the two groups (χ²=2.84,P>0.05).There were no significant differences between the KD complicated with coronary artery injury (CAL) group and non coronary artery lesion (NCAL) group in genotyping frequencies of AG,AA and GG respectively (χ²=3.76,P>0.05) and in the allele frequencies of A and G between the two groups (χ²=0.43,P>0.05). Conclusion The locus rs1800683 G>A polymorphisms of LTA gene maybe not associated with the risks of KD and the coronary artery injury.

Key words: lymphotoxin-alpha gene, polymorphism, Kawasaki disease

中图分类号:

R179

曾才秀,詹霞,周进,谢圭,袁海斌,周钗,杨作成. 淋巴毒素α基因rs1800683 G>A位点多态性与川崎病的关联性研究[J]. 中国儿童保健杂志, 2016, 24(5): 472-474.

ZENG Cai-xiu,ZHAN Xia,ZHOU Jin,XIE Gui,YUAN Hai-bin,ZHOU Chai,YANG Zuo-cheng.. Association of locus rs1800683 G>A polymorphisms of lymphotoxin-alpha gene with Kawasaki disease.[J]. journal1, 2016, 24(5): 472-474.

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淋巴毒素α基因rs1800683 G>A位点多态性与川崎病的关联性研究

Association of locus rs1800683 G>A polymorphisms of lymphotoxin-alpha gene with Kawasaki disease.

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