关键词: 高促甲状腺素血症, 先天性甲状腺功能减低症, 促甲状腺激素, 随访

Abstract: Objective To improve the treatment level of congenital hypothyroidism through researching the clinical outcome of neonatal hyperthyrotropinemia. Methods 446 hyperthyrotropinemia neonates were follow up whose concentration of thyrotropin were 5~20 mU/L and concentration of free thyroxine were normal.Their body growth level and thyroid function were evaluated in 3~6 years old. Results Among them,16 cases were hyperthyrotropinemia,429 cases were normal,and only one child were diagnosed permanent congenital hypothyroidism.Significant differences were found in concentration of thyrotropin between the outset and the end of follow-up. Conclusions With growing-up,the most of these neonates' thyroid function are normal.There should be exactitude follow-up with neonatal hyperthyrotropinemia.Congenital hypothyroidism should be diagnosed and treated as early as possible in hyperthyrotropinemia.

Key words: hyperthyrotropinemia, congenital hypothyroidism, thyrotropin, follow-up