孤独症谱系障碍儿童的磁共振弥散张量成像研究

doi:10.11852/zgetbjzz2014-22-09-03

中国儿童保健杂志 ›› 2014, Vol. 22 ›› Issue (9): 902-905.DOI: 10.11852/zgetbjzz2014-22-09-03

孤独症谱系障碍儿童的磁共振弥散张量成像研究

章丽丽¹, 朱宗明², 张枫¹, 汤群峰², 刘毅梅¹, 姜新宇²

1. 南京医科大学附属无锡市人民医院儿童保健科, 江苏无锡 214023;
2. 南京医科大学附属无锡市人民医院放射影像科, 江苏无锡 214023

收稿日期:2013-09-22 发布日期:2014-09-10 出版日期:2014-09-10
作者简介:章丽丽(1973-), 女, 江苏人, 副主任医师, 硕士学位, 主要研究方向为儿童发育障碍及心理行为问题。

A diffusion tensor imaging studying in children with autism

ZHANG Li-li¹, ZHU Zong-ming², ZHANG Feng¹, TANG Qun-feng², LIU Yi-mei¹, JIANG Xin-yu²

1. Department of Child Health Care,Wuxi People Hospital Affiliated to Nanjing Medical University,Wuxi,Jiangsu 214023,China;
2. Department of Radiology,Wuxi People Hospital Affiliated to Nanjing Medical University,Wuxi,Jiangsu 214023,China

Received:2013-09-22 Online:2014-09-10 Published:2014-09-10

摘要/Abstract

摘要： 目的探讨孤独症谱系障碍儿童重要区域脑白质的磁共振弥散张量成像(diffusion tensor imaging,DTI)特点。方法对37例男性孤独症谱系障碍儿童和16例正常发育男童进行神经心理评估及磁共振弥散张量成像技术扫描,比较两组各向异性分数(fractional anisotropy,FA)的差异,并分析孤独症组感兴趣区FA值与儿童智能发展水平及临床表现之间的关系。结果孤独症谱系障碍组的感兴趣脑区FA值与对照组相比无明显差异(P>0.05)。孤独症谱系障碍组的左侧额叶FA值与智能发展水平有相关性(P<0.05)。孤独症谱系障碍儿童儿童期孤独症评定量表(The Childhood Autism Raling Scale,CARS)分级重度组比轻-中度组左侧额叶FA值更低(P<0.05)。结论左侧额叶白质损伤可能参与了孤独症谱系障碍的病例生理过程的变化。

关键词: 孤独症谱系障碍, 磁共振成像, 弥散, 各向异性

Abstract: Objective To analyze the changes of white matter fiber in child with autism. Methods Diffusion tensor imaging(DTI) data were obtained from 37 autistic children and 16 age-,sex- matched normal controls.Developmental quotient(DQ),Childhood Autism Rating Scale(CARS),Autism Behavior Checklist(ABC)were also examined.The correlation coefficients between fractional anisotropy(FA)in cerebral tissues and DQ,CARS,ABC scores in autistic children were calculated. Results The results showed that there were no significant differences in FA between the autism group and control group(P>0.05).In the autistic group,the FA values in the left frontal gyrus were correlated with the scores of DQ and CARS(P<0.05). Conclusions White matter damage of frontal lobe may play an important role in histopathologic changes associated with autism.

Key words: autism spectrum disorders, MRI, diffusion magnetic resonance imaging, anisotropy

中图分类号:

R749.94

章丽丽, 朱宗明, 张枫, 汤群峰, 刘毅梅, 姜新宇. 孤独症谱系障碍儿童的磁共振弥散张量成像研究[J]. 中国儿童保健杂志, 2014, 22(9): 902-905.

ZHANG Li-li, ZHU Zong-ming, ZHANG Feng, TANG Qun-feng, LIU Yi-mei, JIANG Xin-yu. A diffusion tensor imaging studying in children with autism[J]. journal1, 2014, 22(9): 902-905.

参考文献

[1] Frit C.What do imaging studies tell us about the neural basis of autism?[J].Novartis Found Symp,2003,251:149-166.
[2] 张家健,高振敏,薛红,等.0～4岁小儿发育诊断量表的研究[J].中华儿童保健杂志,1997,5(3):144-147.
[3] 张作记.行为医学量表手册[M/CD].北京:中华医学电子音像出版社,2005:223-224,213-214,476-477,470-471.
[4] 李伟,龙晚生,陈曼琼,等.磁共振弥散张量成像联合纤维束成像在脑梗死中的应用研究[J].国际生物医学工程杂志,2011,34(4):212-217.
[5] 管锦群,王鲁宁,张熙,等.轻度认知功能障碍的磁共振弥散张量成像研究[J].中华内科杂志,2010,49(2):107-110.
[6] Cheng Y,Chou KH,Chen IY.Atypical development of white matter microstructure in adolescents with autism spectrum disorders[J].Neuroimage,2010,15,50(3):873-882.
[7] Weinstein M,Ben-Sira L,Levy Y,et al.Abnormal white matter integrity in young children with autism[J].Hum Brain Mapp,2011,32(4):534-543.
[8] Thomas C,Humphreys K,Jung KJ,et al.The anatomy of the callosal and visual-association pathways in high-functioning autism:a DTI tractography study[J].Cortex,2011,47(7):863-873.
[9] Barnea-Goraly N,Lotspeich LJ,Reiss AL.Similar white matter aberrations in children with autism and their unaffected siblings:a diffusion tensor imaging study using tract-based spatial statistics[J].Arch Gen Psychiatry,2010,10(67):1052-1060.
[10] Ellmore TM,Li H,Xue Z,et al.Tract-based spatial statistics reveal altered relationship between non-verbal reasoning abilities and white matter integrity in autism spectrum disorder[J].J Int Neuropsychol Soc,2013,8:1-6.
[11] 曾小璐,邹小兵,岑超群,等.儿童孤独症的脑扩散张量成像研究[J].中华精神科杂志,2007,40(2):90-94.
[12] 柯晓燕,汤天宇,洪珊珊,等.高功能孤独症患儿全脑白质纤维的弥散张量成像研究[J].中华精神科杂志,2009,42(2):85-88.
[13] Walker L,Gozzi M,Lenroot R,et al.Diffusion tensor imaging in young children with autism:biological effects and potential confounds[J].Biol Psychiatry,2012,15,72(12):1043-1051.
[14] Vomstein K,Stieltjes B,Poustka L,et al.Structural connectivity and diffusion tensor imaging in autism spectrum disorders[J].Z Kinder Jugendpsychiatr Psychother,2013,41(1):59-68.
[15] Li H,Xue Z,Ellmore TM,et al.Network-based analysis reveals stronger local diffusion-based connectivity and different correlations with oral language skills in brains of children with high functioning autism spectrum disorders[J].Hum Brain Mapp,2012,Sep 24.doi:10.1002/hbm.22185

孤独症谱系障碍儿童的磁共振弥散张量成像研究

A diffusion tensor imaging studying in children with autism

PDF

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	张超. 早期介入丹佛模式在不同病情程度孤独症谱系障碍儿童康复中的应用研究[J]. 中国儿童保健杂志, 2023, 31(7): 736-740.
[2]	刘安南, 姜志梅. 孤独症谱系障碍各年龄段筛查工具研究进展[J]. 中国儿童保健杂志, 2023, 31(6): 645-649.
[3]	黎梦晗, 李廷玉. 孤独症谱系障碍儿童感觉异常的研究进展[J]. 中国儿童保健杂志, 2023, 31(6): 650-655.
[4]	刘梦姣, 郑小琴, 孟仙, 吴晓玲, 葛冬梅, 聂晶. 2~5岁孤独症谱系障碍、疑似孤独症谱系障碍及全面发育迟缓儿童的智能特征分析[J]. 中国儿童保健杂志, 2023, 31(6): 668-673.
[5]	李德欣, 陈强, 庄志成, 陈红, 杨秉娇, 姜顺香, 周翔. 孤独症谱系障碍儿童肠道菌群与症状严重程度相关性研究[J]. 中国儿童保健杂志, 2023, 31(5): 497-501.
[6]	王少雯, 张贻霞, 陈静静, 魏秀丽, 叶蓓, 方拴锋. Gesell发展诊断量表在语言相关的发育性疾病中的应用[J]. 中国儿童保健杂志, 2023, 31(4): 442-445.
[7]	柯晓燕. 孤独症谱系障碍早期识别与早期诊断的现状与挑战[J]. 中国儿童保健杂志, 2023, 31(3): 238-240.
[8]	宋超, 胡莉菲, 吴玲玲, 江忠权. 孤独症谱系障碍儿童合并智力功能缺陷的GBM预测模型构建与评价[J]. 中国儿童保健杂志, 2023, 31(3): 241-245.
[9]	李正, 肖贵元, 罗雅婷, 何春燕, 王念蓉, 赵妍. 孤独症谱系障碍儿童血清叶酸、维生素B12水平与肠道菌群的关联[J]. 中国儿童保健杂志, 2023, 31(3): 246-251.
[10]	董海鹏, 杨思渊, 李伟栋, 余婧. 团体社交训练对孤独症谱系障碍儿童康复效果的影响因素及Nomogram预测模型构建[J]. 中国儿童保健杂志, 2023, 31(3): 252-258.
[11]	赵丽华, 李晶. 孤独症谱系障碍儿童非典型人际同步表现及其神经机制[J]. 中国儿童保健杂志, 2023, 31(3): 274-278.
[12]	赵英欣, 何凡, 郑毅. 肠道微生物干预在孤独症谱系障碍中的应用展望[J]. 中国儿童保健杂志, 2023, 31(3): 279-283.
[13]	王静, 黄珊, 高雪婷. 孤独症谱系障碍儿童室内替代座椅干预研究进展[J]. 中国儿童保健杂志, 2023, 31(3): 284-288.
[14]	林欢喜, 刘潘婷, 童梅玲, 池霞, 钱君, 洪琴. 父母介导的干预在孤独症谱系障碍治疗中应用效果的Meta分析[J]. 中国儿童保健杂志, 2023, 31(3): 304-310.
[15]	易爱文, 辛晶, 白艳, 许嘉欣, 梁福鑑, 冯小键. 脑电频谱特征分析在孤独症谱系障碍儿童早期诊断及康复干预评价中的应用[J]. 中国儿童保健杂志, 2023, 31(3): 311-315.