关键词: 卵胞浆内单精子注射技术, 子代, 行为发育, 辅助生殖技术

Abstract: Objective To study the effect of intracytoplasmic sperm injection(ICSI) technology on children′s behavioral development at the preschool period. Methods A 1∶1 case-control study was designed in this study. Children conceived by ICSI in reproduction center and born between January 2009 to December 2010 of the Maternal and Children Healthcare Hospital of Jiaxing were enrolled as ICSI group. Children born at the same time matched by age, gender were recruited as natural conception group (NC group).Family general conditions, born histories and behavioral development at preschool period were investigated retrospectively. Results Totally 16 males and 14 females were enrolled in both group. There were three twins in ICSI group and no twins in NC group(P>0.05). There were no significant differences on parents′ age, educational status, delivery way and birth weight between ICSI group and NC group. The gestational age of ICSI group was significantly lower than that of NC group (37.27±2.39 weeks vs 38.80±1.35 weeks,P<0.05).But there was no significant difference on gestational age after removing three twins.Also, there were no significant differences on the incidence of behavioral problems or hyperactive behavior between two groups at preschool age(P>0.05). Conclusions The behavioral problems in ICSI group are close to NC group until follow up to preschool age.

Key words: intracytoplastic sperm injection technology, offspring, behavioral development, assisted reproductive technology