关键词: 早产儿, 宫内生长发育迟缓, 影响因素

Abstract: Objective To explore the occurrence and hospitalization of intrauterine growth restriction (IUGR) in premature infants,in order to provide guidance for the treatment of premature infants during hospitalization. Methods A total of 200 preterm infants hospitalized in the Department of Neonatology in Children′s Hospital of Soochow University were studied from 2015 to 2017.The perinatal data of these preterm infants,nutrition and disease during hospitalization were analyzed retrospectively. Results Among 200 preterm infants in this study,23.5% (47/200)cases suffered from intrauterine growth restriction(IUGR),of which 10%(20/200) were serious.And 97.9% (46/47) IUGR children developed extrauterine growth retardation(EUGR),68%(32/47) were serious.In children without IUGR,the incidence of EUGR was 51.6%(47/153),and 6.5%(10/153) were serious.There were significant differences on the prevalence of EUGR and severe EUGR between IUGR group and non IUGR group (P<0.01).The smaller the birth weight was,the lower the percentage of the average weight in growth curve at the same gestational age would be (χ²=55.615,P<0.01).And with the increase of birth weight,the incidence of IUGR gradually decreased.Compared with the non IUGR group,the prevalence of pregnancy induced hypertension infants in IUGR group was significantly higher (P<0.01).The duration of milk opening,fasting time and total enteral nutrition time during hospitalization were longer in IUGR group than those in non IUGR group (P<0.05).The level of the lowest globulin in non IUGR group was lower than that of the IUGR group (P<0.05).The prevalence rates of PICC,blood transfusion (severe anemia),pneumonia,septicemia,hypoproteinemia,electrolyte disturbance,feeding intolerance and MRI indicating intracranial lesions were higher than those in non IUGR group (P<0.05). Conclusions The prevalence of IUGR in hospitalized preterm infants is high,and EUGR is more likely to occur in premature infants with IUGR.There were significant differences on the hospitalization conditions between IUGR and non IUGR children.Understanding the characteristics of IUGR preterm children can better guide the clinical treatment.

Key words: premature infants, intrauterine growth restriction, influencing factor