关键词: 早产儿, 追赶性生长, 影响因素, 生长曲线, 随访

Abstract: Objective To explore the influencing factors of physical catch-up growth of premature infants,in order to provide a reference for the subdivision intervention stage of catch-up growth of premature infants and the development of personalized follow-up program. Methods A total of 247 preterm infants admitted to Shanghai Children′s Medical Center from October 2010 to September 2016 and followed up regularly after discharge to the corrected age of 1 year,were evaluated for assessing differences on physical development of preterm infants to analyze the related factors of catch-up growth failed by 1 year old of adjusted age. Results Among 247 preterm infants,206(83.4%) cases got catch-up growth before one year old.Multivariate Logistic regression analysis indicated that extrauterine growth restriction(EUGR) with weight evaluation at discharge (OR=4.586,95%CI:1.712-12.288,P=0.002) was the major risk factor for failing in catch-up growth in preterm infants at the corrected age of one year.High-risk of nutritional risk(OR=4.815,95%CI:1.860-12.467,P<0.001),hypertensive diseases of the mother during pregnancy(OR=2.861,95%CI:1.384-5.914,P=0.005) were risk factors for EUGR with weight evaluation, High birth weight (OR=0.151,95%CI:0.065-0.348,P<0.001) was the protective factor for EUGR with weight evaluation.Moreover, the smaller the birth weight was when the gestational age was lower than 32 weeks,the later preterm infant catches up growth would be.The smaller the gestation age,the head circumference of preterm infant reaches the target more slowly. Conclusion Strengthening the management of premature infants in hospital,especially to giving aggressive and reasonable nutritional support strategies for premature infants,reducing the incidence of EUGR and adhering to regular follow-up guidance can help decrease the occurrence of failed catch-up growth in infants.

Key words: premature infants, catch-up growth, influencing factors, growth curve, follow-up