关键词: 维生素D, 维生素D缺乏/不足, 早产儿

Abstract: Objective To evaluate the effect of different doses of vitamin D supplementation on vitamin D level of preterm infants with gestational age ≤34 weeks at discharge,in order to provide evidence for the post-natal vitamin supplementation of premature infants. Methods A total of 67 premature infants with gestational age 34 weeks or less in Boluo Maternal and Child Care Hospital from January 2019 and June 2020 were randomly divided into low-dose group(32 cases) and high-dose group(n=35) after full enteral feeding. Then the discharge level of 25(OH)D,vitamin D insufficiency and related adverse reactions were compared. Results There was no statistically significant difference in the level of 25 (OH) D of umbilical cord blood at birth between low-dose group and high-dose group (P>0.05). The serum 25 (OH) D level of infants in the high-dose group was significantly higher than that of the low-dose group(t=2.872,P＜0.05). The incidence of vitamin D deficiency/insufficiency at discharge in the high-dose group was significantly lower than that in the low-dose group (χ²=4.189,P＜0.05). However,the incidence of vitamin D deficiency/deficiency in the high-dose group still reached to 28.6%. Conclusions For premature infants with gestational age ≤34 weeks,supplementing vitamin D at 800 U/d can significantly improve the deficiency or insufficiency of vitamin D at discharge. However,for ultra-low birthweight infants with lower gestational age and lower birth weight,a larger dose of vitamin D supplementation may be required.

Key words: vitamin D, vitamin D deficiency/insufficiency, premature infants