关键词: 儿童肥胖, 肺功能, 维生素D

Abstract: Objective To analyze the characteristics of pulmonary ventilation function in school-age obese children and its correlation with serum 25-hydroxyvitamin D [25-(OH)D], and to explore the mechanism of the effect of vitamin D on the pulmonary function of obese children. Methods Totally 104 obese children aged 6-12 years were recruited from January 2019 to January 2020 to measure their height, body mass, serum 25-(OH)D level and pulmonary ventilation function.Pulmonary ventilation function parameters were compared in obese children with deficient, insufficient and appropriate serum vitamin D level.Multiple linear regression was used to analyze the correlation between serum vitamin D and pulmonary function parameters. Results The lung function parameters in mild to moderate obesity group were higher than those in severe obesity group, and the differences in FEF50% and MMEF between the two groups was significant (t=2.808,2.164, P<0.05).The difference in FEV1, FVC, PEF, FEF25%, FEF50% and FEF75% were significant among obese children with deficient, insufficient and appropriate serum vitamin D level(F=3.988, 4.758, 3.142, 5.186, 3.478, 3.220, P<0.05).Multiple linear regression showed that pulmonary function parameters FEV1, FVC, PEF, FEF25%, FEF50%, FEF75% and MMEF were positively linear correlated with serum 25-(OH)D level (B=0.341, 0.315, 0.371, 0.745, 0.665, 0.715, 0.613, P<0.05).Significant correlation was not found between FEV1/FVC, FEV1/FVC% and serum 25-(OH)D level. Conclusion There is a linear positive correlation between serum 25-(OH)D level and some lung function parameters of school-age obese children, which may be a protective factor of lung function of obese children.

Key words: childhood obesity, pulmonary function, vitamin D