关键词: 25羟维生素D, 贫血, 南京市, 婴幼儿

Abstract: Objective To analyze the level of 25 hydroxyvitamin D[25-(OH)D] in infants aged 0-3 years in Nanjing, and to explore its correlation with anemia. Methods A total of 1 143 children aged 0-3 years old who underwent routine physical examination in the children health clinic of women and children's branch of Jiangsu Province Hospital from August 2017 to October 2019 were enrolled in this study.The levels of 25-(OH)D and hemoglobin (Hb) of peripheral blood were tested and the correlation between the level of 25-(OH)D and Hb in different age groups was analyzed. Results The average level of 25-(OH)D was (79.03±25.71) nmol/L in 1 143 infants aged 0~3 years, among whom 113 (9.88%) were deficient, 451 (39.46%) were insufficient, and 579 (50.66%) were adequate.The difference on 25-(OH)D level in different age groups was significant (F=25.26, P<0.01), with the lowest level in the 2 to 3 years old group.122 cases (10.67%) suffered from anemia, and 1 021 cases (89.33%) were non-anaemic.The detection rate of anemia in 25-(OH)D deficiency group was significantly higher than that in adequate group (χ² =8.261, P=0.004).Pearson correlation analysis showed that there was a positive correlation between the level of 25-(OH)D and Hb in the groups of 0 to 0.5 year old, 0.5 to 1 year old, and 1 to 2 years old (r=0.288,0.274,0.123, P<0.05), while no correlation was found in the group of 2 to 3 years old (r=0.080,P=0.264). Conclusions The overall rate of 25-(OH)D deficiency and insufficiency is relatively high in infants aged 0 to 3 years in Nanjing.And there is a positive correlation between the level of 25-(OH)D and Hb in infants aged 0 to 2 years, suggesting that the lack of 25-(OH)D may affect the generation of Hb and be related to the occurrence of anemia in infants.

Key words: 25-hydroxyvitamin D, anemia, Nanjing, infants