对氧磷酶2与白三烯受体在儿童支气管哮喘中表达的相关性及临床生物学意义

doi:10.11852/zgetbjzz2017-25-08-27

中国儿童保健杂志 ›› 2017, Vol. 25 ›› Issue (8): 843-845.DOI: 10.11852/zgetbjzz2017-25-08-27

对氧磷酶2与白三烯受体在儿童支气管哮喘中表达的相关性及临床生物学意义

程玮¹,王贞¹,王静¹,闫堃²

1 西安市儿童医院呼吸二科,陕西西安 710004;
2 西安交通大学医学院第二附属医院普通外科,陕西西安 710004

收稿日期:2016-12-22 发布日期:2017-08-10 出版日期:2017-08-10
作者简介:程玮(1976-),女,陕西人,副主任医师,博士研究生,主要研究方向为儿童呼吸系统疾病。
基金资助:
陕西省社会发展攻关项目资助(2011K13-03-11)

Express of PON2 and LTSR in the children of the bronchial asthma and relevance with clinical biological significance

CHENG Wei¹,WANG Zhen¹,WANG Jing¹,YAN Kun²

1 The 2^nd Pneumology Department of Xi'an Children Hospital,Xi'an,Shaanxi 710004,China;
2 Department of General Surgery,the Second Hospital Affiliated to Medical School of Xi'an Jiaotong University,Xi'an,Shaanxi 710004,China

Received:2016-12-22 Online:2017-08-10 Published:2017-08-10

摘要/Abstract

摘要： 目的研究对氧磷酶2与白三烯受体在儿童支气管哮喘中表达的相关性及临床生物学意义,为儿童哮喘发病机制提供分子病理学研究基础。方法以正常儿童群体为对照采用双抗体夹心ELISA法比较对氧磷酶2与白三烯受体在儿童支气管哮喘不同亚组及缓解组中的差异。结果对氧磷酶2与白三烯受体的表达在正常儿童、哮喘急性发作患儿中存在明显差异。哮喘患儿根据其症状严重程度分组,轻症组与重症组差异有统计学意义(P<0.01或<0.05),且其表达水平与症状存在正相关关系,r值分别为0.81和0.73(P<0.05)。结论对氧磷酶2与白三烯受体可作为独立风险预测因子判定儿童哮喘的演进和转归。

关键词: 血清炎性因子, 受体, 儿童支气管哮喘, 酶联免疫吸附试验

Abstract: Objective To investigate the relationship between serum paraoxonase 2 and lekukotriene receptor expression in children with bronchial asthma and explore its clinical significance. Methods Compare the serum paraoxonase 2 and leukotriene receptor of different groups in children with bronchial asthma by ELISA,which take the normal children as control. Results There were obvious differences in the expression of the serum paraoxonase 2 and leukotriene receptor between normal children and bronchial asthma cases.Also,there was positive correlation among the severity grade of symptom and their expression level.The r values were 0.81 and 0.73 (P<0.05). Conclusion The paraoxonase 2 and leukotriene receptor can be used as an independent risk factor to detect the prognosis of children with bronchial asthma.

Key words: serum paraoxonase 2, leukotriene receptors, bronchial asthma, Enzyme-linked immunosorbent assay

中图分类号:

R179

程玮,王贞,王静,闫堃. 对氧磷酶2与白三烯受体在儿童支气管哮喘中表达的相关性及临床生物学意义[J]. 中国儿童保健杂志, 2017, 25(8): 843-845.

CHENG Wei,WANG Zhen,WANG Jing,YAN Kun. Express of PON2 and LTSR in the children of the bronchial asthma and relevance with clinical biological significance[J]. journal1, 2017, 25(8): 843-845.

参考文献

[1] Wade A,Chang C.Evaluation and treatment of critical asthmasyndrome in children[J].Clinical Reviews in Allergy & Immunology,2015,48(1):66-83.
[2] Kenyon N,Zeki AA,Albertson TE,et al.Definition of critical asthma syndromes[J].Clinical Reviews in Allergy & Immunology,2015,48(1):1-6.
[3] Silva CM,Barros L,Simes F.Health-related quality of life in paediatric asthma:Children's and parents' perspectives[J].Psychology,Health & Medicine,2015,20(8):940-954.
[4] Vu LT,Demoulin B,Nguyen MT,et al.Respiratory impedance and response to salbutamol in asthmatic Vietnamese children[J].Pediatric Pulmonology,2010,45(4):380-386.
[5] Uzuner N,Babayigit Hocaoglu A,Olmez Erge D,et al.Raised interleukin-13 levels in cord blood increases the risk of allergic sensitization at 5 years of age[J].Iranian Journal of Allergy,Asthma,and Immunology,2013,12(2):107-114.
[6] Pietracupa S,Bruno E,Cavanna AE,et al.Scales for hyperkinetic disorders:A systematic review.Journal of the Neurological Sciences,2015,358(1-2):9-21.
[7] Haider S,Mannan N,Khan A,et al.Influence of anthropometric measurements on abnormal gonadotropin secretion in women with polycystic ovary syndrome[J].Journal of the College of Physicians and Surgeons-Pakistan:JCPSP,2014,24(7):463-466.
[8] Rosenberg J,Jhaveri P,Kelbel T.Laronidase desensitization during stem cell transplant in a child with Hurler syndrome[EB/OL].Annals of allergy,asthma &immunology:official publication of the American College of Allergy,Asthma,& Immunology,2016,ahead print.
[9] Lee JH,Han KD,Kim KM,et al.Prevalence of atopic dermatitis in Korean children based on data from the 2008-2011 Korean National Health and Nutrition Examination Survey[J].Allergy,Asthma & Immunology Research,2016,8(1):79-83.
[10] Klamt S,Vogel M,Kapellen TM,et al.Association between IgE-mediated allergies and diabetes mellitus type 1 in children and adolescents[J].Pediatric Diabetes,2015,16(7):493-503.
[11] Pyun BY.Extracellular vesicle:An unknown environmental factor for causing airway disease[J].Allergy,Asthma & Immunology Research,2016,8(3):179-180.
[12] Bobin-Dubigeon C,Lefranois A,Classe JM,et al.Paired measurement of serum amyloid A (SAA) and paraoxonase 1 (PON1) as useful markers in breast cancer recurrence[J].Clinical Biochemistry,2015,48(16-17):1181-1183.
[13] 刘艳琳,唐素萍,董李,等.福建省福州地区儿童慢性咳嗽临床特征和治疗现况[J].中国儿童保健杂志,2016,24(11):1194-1196.
[14] Cingi C,Muluk NB,Ipci K,et al.Antileukotrienes in upper airway inflammatory diseases[J].Current Allergy and Asthma Reports,2015,15(11):64-65.
[15] 冯金环,王孟兰,张俊英,等.支气管哮喘儿童血清sFas、sFasL的临床意义[J].中国儿童保健杂志,2016,24(8):887-888.
[16] Mashima R,Okuyama T.The role of lipoxygenases in pathophysiology;new insights and future perspectives[J].Redox Biology,2015,(10):6297-6310.

对氧磷酶2与白三烯受体在儿童支气管哮喘中表达的相关性及临床生物学意义

Express of PON2 and LTSR in the children of the bronchial asthma and relevance with clinical biological significance

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