叶酸对孤独症儿童的辅助治疗效果研究

中国儿童保健杂志 ›› 2013, Vol. 21 ›› Issue (1): 13-15.

叶酸对孤独症儿童的辅助治疗效果研究

李楠楠,夏薇,孙彩虹,赵栋,吴坤

哈尔滨医科大学公共卫生学院,黑龙江哈尔滨 150081

收稿日期:2012-08-14 发布日期:2013-01-06 出版日期:2013-01-06
通讯作者: 吴坤,E-mail:wukun_15000@126.com
作者简介:李楠楠(1986-),女,山东人,硕士在读,研究方向为特殊人群营养干预。
【通信作者】吴坤,E-mail:wukun_15000@126.com
基金资助:
国家自然科学基金(81072298)

Efficacy of folic acid supplementation as an adjuvant therapy in treatment of children with autism

LI Nan-nan,XIA Wei,SUN Cai-hong,ZHAO Dong,WU Kun.

Public Health College,Harbin Medical University,Harbin,Heilongjiang 150081,China

Received:2012-08-14 Online:2013-01-06 Published:2013-01-06

摘要/Abstract

摘要： 目的探讨叶酸对参与结构化教育的孤独症儿童的辅助治疗效果，为进行靶向营养干预及综合辅助治疗提供科学依据。方法采用开放性试验方法。随访66名参与结构化教学的孤独症儿童，遵循自愿原则分为叶酸干预组和对照组，采用孤独症行为量表（Autism Behavior Scale,ABC）、儿童孤独症评定量表（Children's Autism Rating Scale,CARS）、孤独症治疗评估量表（Autism Treatment Evaluation Checklist,ATEC）和自闭症儿童心理教育评核第3版（PEP3）对其3个月前后的发育水平进行评估比较。结果经过3个月的康复训练后，两组儿童ABC、CARS、ATEC量表总分均降低，PEP3量表各项得分（除行为特征非语言外）均有提高，且差异具有统计学意义（P<0.05）；训练前后各量表差值显示，叶酸干预组孤独症儿童ATEC量表中的语言交流项、PEP3量表中的认知、语言理解和语言表达项的差值高于对照组，且差异具有统计学意义（P<0.05）。结论孤独症儿童在参与结构化教学的同时补充叶酸，对认知和语言交流的改善作用优于单纯参与结构化教学。

关键词: 孤独症, 结构化教学, 叶酸干预, 治疗

Abstract: Objective To study the efficacy of folic acid supplementation as an adjuvant therapy in treatment of children with autism participated in structured teaching. Methods The method of open trial was used in this study.66 autistic children participated in structured teaching were divided into folic acid intervention group and control group based on the principle of voluntariness.Developmental progress was measured by Autism Behavior Scale (ABC),Children's Autism Rating Scale (CARS),Autism Treatment Evaluation Checklist (ATEC) and Psychoeducational Profile-Third Edition (PEP-3) before and after 3 months' treatment. Results Compared with 3 months before,the overall scores of ABC,CARS and ATEC of both groups were significantly lower than before (P<0.05),while the scores of all items of PEP-3 scale were higher than before (P<0.05),except for character motor behavior.According to the differentials of each scale before and after treatment,intervention group showed greater progress in language of ATEC and cognition,expressive language and receptive language of PEP-3 scale than those of control group (P<0.05). Conclusions Autism children participated in structured teaching with folic acid intervention presents greater progress in cognition and language than those in independent structured teaching.

Key words: autism, structured teaching, folic acid intervention, therapy

中图分类号:

R749.94

李楠楠,夏薇,孙彩虹,赵栋,吴坤. 叶酸对孤独症儿童的辅助治疗效果研究[J]. 中国儿童保健杂志, 2013, 21(1): 13-15.

LI Nan-nan,XIA Wei,SUN Cai-hong,ZHAO Dong,WU Kun.. Efficacy of folic acid supplementation as an adjuvant therapy in treatment of children with autism[J]. journal1, 2013, 21(1): 13-15.

参考文献

[1] Chen YH,Rodgers J,McConachie H.Restricted and repetitive behaviours,sensory processing and cognitive style in children with autism spectrum disorders[J].J Autism Dev Disord,2009,39:635-642.
[2] 江瑞芬,杨虹,王小林,等.结构化教育治疗儿童孤独症的疗效[J].中国儿童保健杂志,2006,14 (4):478-480.
[3] 梁爽,粟丽群,王佳,等.孤独症患儿45例短期综合训练疗效评价[J].中国学校卫生,2010,31(2):141-143.
[4] Paolo M,Sarika UP,Daniela del G,et al.Brief report:autistic symptoms,developmental regression,mentl retardation,epilepsy,and dyskinesias in CNS folate deficiency[J].J Autism Dev Disorder,2008,38:1170-1177. [5] James SJ,Melnyk S,Fuchs G,et al.Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism1-3[J].Am J Clin Nutr,2009,89:1-6.
[6] Daniel AR,Faafp MD.Novel and emerging treatments for autism spectrum disorders:A systematic review[J].Annals of Clinical Psychiatry,2009,21(4):213-236.
[7] Panerai S,Zingalem,Trubiag,et al.Special education versus inclusive education:The role of the TEACCH program[J].J Autism Dev Disord,2009,39(6):874-882.
[8] Siaperas P,Beadle BJ.A case study of the use of a structured teaching approach in adults with autism in a residential home in Greece[J].Autism,2006,10:330-343.
[9] 邹小兵,邓红珠,唐春,等.以家庭为基地的短期结构化教育治疗儿童孤独症的疗效[J].中国儿童保健杂志,2005,13(2):98-100.
[10] 程道梅,蒋与刚,黄承钰,等.同型半胱氨酸血症患者的亚甲基四氢叶酸还原酶基因多态性、血清维生素状况及认知功能[J].Danone Institute China,2009,2:115-121.
[11] Ramaekers VT,Hausler M,Methyltetr Opladen T,et al.Psychomotor retardation,spastic paraplegia,cerebellar ataxia and dyskinesia associated with 5-methyletrahydrofolate in cerebrospinal fluid:a novel neurometabolic condition responding to folinic acid substitution[J].Neuropediatrics,2002,33:301-308.
[12] Moretti P,Sahoo T,Hyland K,et al.Cerebral folate deficiency with developmental delay,autism,and response to folinic acid[J].Neurology,2005,64:1088-1090.
[13] Frye RE,Sequeira JM,Quadro EV,et al.Cerebral folate receptor autoantibodies in autism spectrum disorder[M].Molecular Psychiatry,2012:1-13.
[14] Liselotte K,Asa H.Language and communication skills in preschool children with autism spectrum disorders:contribution of cognition,severity of autism symptoms,and adaptive functioning to the variability[J].Research in Developmental Disabilities,2012,33:172-180.

[1]	李荣, 李年, 吴丹丹, 黄荣, 陈银花. 盐酸哌甲酯缓释片对注意缺陷多动障碍儿童生长的影响[J]. 中国儿童保健杂志, 2023, 31(7): 731-735.
[2]	张超. 早期介入丹佛模式在不同病情程度孤独症谱系障碍儿童康复中的应用研究[J]. 中国儿童保健杂志, 2023, 31(7): 736-740.
[3]	刘安南, 姜志梅. 孤独症谱系障碍各年龄段筛查工具研究进展[J]. 中国儿童保健杂志, 2023, 31(6): 645-649.
[4]	黎梦晗, 李廷玉. 孤独症谱系障碍儿童感觉异常的研究进展[J]. 中国儿童保健杂志, 2023, 31(6): 650-655.
[5]	刘梦姣, 郑小琴, 孟仙, 吴晓玲, 葛冬梅, 聂晶. 2~5岁孤独症谱系障碍、疑似孤独症谱系障碍及全面发育迟缓儿童的智能特征分析[J]. 中国儿童保健杂志, 2023, 31(6): 668-673.
[6]	李德欣, 陈强, 庄志成, 陈红, 杨秉娇, 姜顺香, 周翔. 孤独症谱系障碍儿童肠道菌群与症状严重程度相关性研究[J]. 中国儿童保健杂志, 2023, 31(5): 497-501.
[7]	曾红玲, 周怡, 谢俊, 戴利莎, 汤珺. 基于结构化教学法的小组训练对学龄前孤独谱系障碍儿童的疗效分析[J]. 中国儿童保健杂志, 2023, 31(5): 564-569.
[8]	王少雯, 张贻霞, 陈静静, 魏秀丽, 叶蓓, 方拴锋. Gesell发展诊断量表在语言相关的发育性疾病中的应用[J]. 中国儿童保健杂志, 2023, 31(4): 442-445.
[9]	柯晓燕. 孤独症谱系障碍早期识别与早期诊断的现状与挑战[J]. 中国儿童保健杂志, 2023, 31(3): 238-240.
[10]	宋超, 胡莉菲, 吴玲玲, 江忠权. 孤独症谱系障碍儿童合并智力功能缺陷的GBM预测模型构建与评价[J]. 中国儿童保健杂志, 2023, 31(3): 241-245.
[11]	李正, 肖贵元, 罗雅婷, 何春燕, 王念蓉, 赵妍. 孤独症谱系障碍儿童血清叶酸、维生素B12水平与肠道菌群的关联[J]. 中国儿童保健杂志, 2023, 31(3): 246-251.
[12]	董海鹏, 杨思渊, 李伟栋, 余婧. 团体社交训练对孤独症谱系障碍儿童康复效果的影响因素及Nomogram预测模型构建[J]. 中国儿童保健杂志, 2023, 31(3): 252-258.
[13]	赵丽华, 李晶. 孤独症谱系障碍儿童非典型人际同步表现及其神经机制[J]. 中国儿童保健杂志, 2023, 31(3): 274-278.
[14]	赵英欣, 何凡, 郑毅. 肠道微生物干预在孤独症谱系障碍中的应用展望[J]. 中国儿童保健杂志, 2023, 31(3): 279-283.
[15]	王静, 黄珊, 高雪婷. 孤独症谱系障碍儿童室内替代座椅干预研究进展[J]. 中国儿童保健杂志, 2023, 31(3): 284-288.