journal1 ›› 2014, Vol. 22 ›› Issue (4): 405-407.DOI: 10.11852/zgetbjzz2014-22-04-21

Previous Articles     Next Articles

Application of hydrogen proton magnetic resonance spectroscopy in infantile spasms.

DU Kai-xian1, WANG Jun-fang1, ZHAO Xin2, JIA Tian-ming1.   

  1. 1 Department of Pediatrics, 2 Department of Radiology, the Third Clinical College of Zhengzhou University, Zhengzhou, Henan 450052, China
  • Received:2013-10-30 Online:2014-04-10 Published:2014-04-10

氢质子磁共振波谱在婴儿痉挛症中的应用

杜开先1, 王军芳1, 赵鑫2, 贾天明1   

  1. 郑州大学第三附属医院1 儿神经内科;2 放射科, 河南 郑州 450052
  • 作者简介:杜开先(1972-), 男, 河南人, 研究生学历, 副教授, 主要研究方向为小儿神经系统疾病。

Abstract: Objective To study the brain biochemical metabolism changes of infantile spasms through hydrogen proton magnetic resonance spectroscopy(1HMRS). Methods A total of 40 cases of infantile spasms and 10 age-matched normal infants were performed brain 1.5T MRI and multi-voxel 1H-MRS exminations, volume of interest (VOI) included thalamus, basal ganglia, temporal lobe, the signal intensities of N-acetylaspartate(NAA), creatine+phosphocreatine (Cr), choline-containig compounds(Cho) were obtained, the ratios of NAA/Cho+Cr, Cho/Cr, and NAA/Cr were set into comparison bilaterally between the patients and controls. Results 1)The ratios of NAA/Cho+Cr, NAA/Cho, NAA/Cr were lower than normal group(P<0.01), and the ratios of Cho/Cr were increased than normal group, the difference were statistically significant(P all <0.01).2)High lac peak could be seen in areas of lesions often. Conclusion The 1H-MRS can noninvasively evaluate changes of cerebral metabolism in infantile spasms.

Key words: infantile spasms, hydrogen proton magnetic resonance spectroscopy, volume of interest, biochemical metabolism

摘要: 目的 通过氢质子磁共振波谱分析(1H-MRS)探讨婴儿痉挛症患儿脑内生化代谢的改变, 为临床诊治提供依据。方法 利用1.5T超导MRI扫描仪对住院的40例婴儿痉挛症患儿与10例同龄正常的婴幼儿颅脑行MRI平扫和1HMRS检查, 选取相同感兴趣区:双侧丘脑、基底节区、颞叶, 获得脑组织的波谱曲线图及N-乙酰天门冬氨酸(NAA)、胆碱(Cho)、肌酸(Cr)的相对浓度。结果 1)病例组中基底节区、丘脑区、颞叶NAA/Cho+Cr、NAA/Cho 、NAA/Cr比值较对照组下降, Cho/Cr比值较对照组升高, 差异有统计学意义(P<0.01);2)病灶区域常可见高大乳酸峰。结论 1H-MRS能无创性评估婴儿痉挛症患儿脑内生化代谢的变化。

关键词: 婴儿痉挛症, 氢质子磁共振波谱成像, 感兴趣区, 生化代谢

CLC Number: