Abstract: Objective To analyze the changes of white matter fiber in child with autism. Methods Diffusion tensor imaging(DTI) data were obtained from 37 autistic children and 16 age-,sex- matched normal controls.Developmental quotient(DQ),Childhood Autism Rating Scale(CARS),Autism Behavior Checklist(ABC)were also examined.The correlation coefficients between fractional anisotropy(FA)in cerebral tissues and DQ,CARS,ABC scores in autistic children were calculated. Results The results showed that there were no significant differences in FA between the autism group and control group(P>0.05).In the autistic group,the FA values in the left frontal gyrus were correlated with the scores of DQ and CARS(P<0.05). Conclusions White matter damage of frontal lobe may play an important role in histopathologic changes associated with autism.

Key words: autism spectrum disorders, MRI, diffusion magnetic resonance imaging, anisotropy

摘要： 目的 探讨孤独症谱系障碍儿童重要区域脑白质的磁共振弥散张量成像(diffusion tensor imaging,DTI)特点。方法 对37例男性孤独症谱系障碍儿童和16例正常发育男童进行神经心理评估及磁共振弥散张量成像技术扫描,比较两组各向异性分数(fractional anisotropy,FA)的差异,并分析孤独症组感兴趣区FA值与儿童智能发展水平及临床表现之间的关系。结果 孤独症谱系障碍组的感兴趣脑区FA值与对照组相比无明显差异(P>0.05)。孤独症谱系障碍组的左侧额叶FA值与智能发展水平有相关性(P<0.05)。孤独症谱系障碍儿童儿童期孤独症评定量表(The Childhood Autism Raling Scale,CARS)分级重度组比轻-中度组左侧额叶FA值更低(P<0.05)。结论 左侧额叶白质损伤可能参与了孤独症谱系障碍的病例生理过程的变化。

关键词: 孤独症谱系障碍, 磁共振成像, 弥散, 各向异性