Abstract: Objective To investigate the effect of post-discharge formula (PDF) to preterm and low-birth-weight infants. Methods A total of 59 preterm and low-birth-weight infants discharged from The NICU of the Second Hospital of Tianjin Medical University were chosen for this study.According to feeding pattern,they were assigned to two groups:breast milk (BM)+PFT-fed(group Ⅰ,n=29),PDF-fed(group Ⅱ,n=30).Their body weight,length and head circumference and so on were measured for 6 months after hospital.These indices were calculated and compared respectively on every month after feeding. Results There were no significant differences on gender,gestational age and birth weight between groupⅠ and groupⅡ (P>0.05).There were no difference on body weight and Kaup index until the end of 3^rd month (P<0.05),and the growth of the groupⅡwas faster than that of groupⅠ.There was no difference on length until the end of 4^rd month (P<0.05),and the growth of groupⅡwas faster than that of groupⅠ.Group Ⅱhad a greater head circumference than groupⅠafter the fifth month (P<0.05).And at the fifth and sixth month,the Hemoglobin value also showed diference between two groups (P<0.05).There were no differences on Ca,P,alkline phosphatase (AKP) after feeding. Conclusions Compared with those fed with BM+PTF after hospital,feeding with PDF can help to achieve catch-up growth.Feeding with PDF may be better than those fed with BM+PTF.

Key words: preterm infant, breast milk, post-discharge formula, low birth weight

摘要： 目的 探讨早产儿出院后配方奶对早产/低出生体重儿生长发育的影响。方法 将59 例早产/低出生体重儿根据出院后喂养方式分为母乳+早产儿配方奶混合喂养组(Ⅰ组)和早产儿出院后配方奶喂养组(Ⅱ组),监测入组后6个月内体重、身长、头围、Kaup指数及部分理化指标,并作组间比较,藉此评价早产儿出院后配方奶对出院后的早产/低出生体重儿生长发育影响的临床意义。结果 入组时两组在性别比例、孕周和出生体重上差异无统计学意义(P>0.05)。体重、Kaup指数,在喂养后2月内差异无统计学意义(P>0.05),从3个月始Ⅱ组较Ⅰ组增长快(P<0.05);身长从第4个月,头围从第5个月起,Ⅱ组较Ⅰ组增长快(P<0.05);血色素从第5个月以后,Ⅱ组高于Ⅰ组(P<0.05)。观测过程中两组的Ca、P、AKP差异无统计学意义(P>0.05)。结论 早产儿出院后配方奶是早产儿出院后喂养品的良好选择,有益于低体重早产儿实现追赶性生长。

关键词: 早产儿, 母乳, 早产儿出院后配方奶, 低出生体重