Abstract: Objective To explore the association between birth weight and the risk of childhood acute lymphoblastic leukemia (ALL). Methods The studies were searched through Medline, PubMed, Web of Science, Cochrane Library, and the retrieving deadline was 2014.Search terms included "acute lymphoblastic leukemia", "childhood", "birth weight".The information of birth weight was extracted, and the quality of the studies was evaluated.STATA12.0 software package was used to calculate the OR and CI 95%, heterogeneity, sensitivity and publication bias of the Meta-analysis. Results A total of 16 studies included 16 934 childhood ALL case and 54 733 control were identified.The Results suggested that there was association between birth weight and the risk of childhood acute lymphoblastic leukemia[≥2 500 g vs <2 500 g(OR=1.17, 95%CI=1.07~1.28), ≥3 500 g vs <3 500 g(OR=1.12, 95%CI=1.04~1.22), ≥4 000 g vs <4 000 g(OR=1.20, 95%CI=1.12~1.27), ≥4 500 g vs <4 500 g(OR=1.27, 95%CI=1.09~1.47)]. Conclusion There is association between birth weight and the risk of childhood acute lymphoblastic leukemia, and the high birth weight is the risk factor of childhood acute lymphoblastic leukemia.

Key words: childhood acute lymphoblastic leukemia, birth weight, Meta-analysis

摘要： 目的 系统探讨儿童急性淋巴细胞白血病(acute lymphoblastic leukemia, ALL)与出生体重的关联性。方法 计算机检索Medline、PubMed、Web of Science、Cochrane Library等英文数据库收集相关文献, 检索时间截止到2014年。检索关键词为“acute lymphoblastic leukemia”、“childhood”、“birth weight”, 对纳入文献提取相关资料并进行质量评价。通过STATA12.0软件对提取的数据进行meta分析, 计算比值比OR及95%置信区间, 并进行异质性、敏感性和发表偏倚的统计分析。结果 本次研究共纳入文献16篇, 包括16 934例病例和54 733例对照。Meta分析结果显示儿童ALL与出生体重之间存在关联性[≥2 500 g vs <2 500 g(OR=0.17, 95%CI=1.07~1.28)、≥3 500 g vs <3 500 g(OR=1.12, 95%CI=1.04~1.22)、≥4 000 g vs <4 000 g(OR=1.20, 95%CI=1.12~1.27)、≥4 500 g vs <4 500 g(OR=1.27, 95%CI=1.09~1.47)]。结论 儿童ALL与出生体重存在关联性, 较大的出生体重是儿童ALL的危险因素。

关键词: 儿童急性淋巴细胞白血病, 出生体重, Meta分析