Abstract: Objective To observe the different feeding way of premature infant growth and evaluate the status of the growth of breast-fed premature infants supplemented with powdered human milk fortifier. Methods Totally 102 infants with gestational age <35 weeks were enrolled and divided into fortified human milk group (31 cases),human milk group (33 cases) and preterm formula group (38 cases).Physical growth speed,hemoglobin and blood calcium of three groups were monitored,and comparative analysed in correct gestational age term (40 weeks) and after 1 month,3 months. Results When the rate of weight gain in the correct term gestational age,after corrected gestational age 1 month and 3 months,fortified human milk group were higher than human milk group and preterm formula group.Three groups' incidences in feeding intolerance,necrotizing enterocolitis (NEC) and other differences were not statistically significant (P> 0.05). Conclusions Premature infants fed with fortified human milk can promote the growth better,especially in weight growth rate and the risk of feeding intolerance and NEC don't increase.It can be used as the preferred way of feeding in preterm neonates.

Key words: breast milk, premature infants, human milk fortifier, growth

摘要： 目的 观察强化母乳喂养对早产儿生长发育的促进作用,为母乳强化剂的临床应用提供依据。方法 出生胎龄<35周的102例早产儿按照喂养方式不同分为强化母乳组(31例),母乳喂养组(33例)和配方奶喂养组(38例)。分别于纠正胎龄足月(40周)及其后1个月、3个月监测三组的体格生长速度、血红蛋白、血钙等指标,并进行对比分析。结果 体重增长速率在纠正胎龄足月时、纠正胎龄后的1个月和3个月,强化母乳组均高于母乳喂养组和配方奶喂养组。三组在喂养不耐受、坏死性小肠结肠炎等发生率方面差异无统计学意义(P>0.05)。结论 强化母乳喂养能够较好的促进早产儿生长,尤其在体重增长速率方面具有优势,同时并不增加喂养不耐受和坏死性小肠结肠炎的风险,可以作为早产儿首选的喂养方式。

关键词: 母乳, 早产儿, 母乳强化剂, 生长
中图分类号:R179 文献标识码:A 文章编号:1008-6579(2015)10-1063-04 doi:10.11852/zgetbjzz2015-23-10-17