Abstract: Objective To investigate a variety of related factors for intracranial hemorrhage(ICH) in premature infants. Methods A case-control study was performed between cases with ICH and cases of non-ICH premature infants.All the subjects were the in-patient newborns from April 2013 to March 2014.Data of the related factors were processed with both χ² test and multiple Logistic regression analysis. Results The statistic analysis showed that fetal distress,gestational age ＜34 weeks,mechanical ventilation and electrolyte disturbance were significant risk factors for ICH.Prenatal application of dexamethasone was a favorable factor. Conclusions In order to prevent and cure ICH at an early stage,monitoring of high risk gravida,correct management of complications,prenatal application of dexamethasone and so on should be advocated.

Key words: premature infants, intracranial hemorrhage, related factors, clinical study

摘要： 目的 探讨早产儿颅内出血(intracranial hemorrhage,ICH)相关因素,为预防脑室周围-脑室内出血(periventricular-intraventricular hemorrhage,PIVH)、脑实质出血、蛛网膜下腔出血提供参考依据。方法 选择2013年4月-2014年3月住院的确诊ICH的早产儿为病例组,同期住院非ICH早产儿为对照组,对相关因素进行回顾性研究。单因素分析用χ²检验,多因素分析用多元Logistic 回归分析。结果 Logistic回归分析确定宫内窘迫、胎龄小于34周、机械通气、电解质紊乱为早产儿ICH独立危险因素,产前应用地塞米松是ICH的有利因素。结论 加强对高危孕产妇孕期监测,及时发现和处理妊娠合并症,产前适时应用地塞米松等可减少早产儿ICH的发生。

关键词: 早产儿, 颅内出血, 相关因素, 临床分析