Detection and significance of plasma D-dimer in early neonatal common diseases

doi:10.11852/zgetbjzz2017-25-02-21

Abstract

Abstract: Objective To investigate the clinical significance of plasma D-dimer level in early neonatal common diseases. Methods Venous blood samples were collected from 300 cases of neonatal common diseases (experimental group) and 50 cases of healthy newborns (control group).The level of D-dimer was tested by ELISA. Results Compare with the healthy control group (320.4±145.5),D-dimer levels of mild (1 167.5±683.7) and severe (5 399.5±3 123.3) neonatal asphyxia groups were both significantly increased,especially in severe neonatal asphyxia group.Compared with healthy control group (320.4±145.5),the D-dimer levels of neonatal pneumonia group (2 406.8±1 559.5) significantly increased.The D-dimer levels of neonatal respiratory distress syndrome (NRDS) group (1 975.6±1 205.66) and neonatal jaundice group (401.13±229.15) significantly increased compared with healthy control group (320.44±145.58),while neonatal wet lung disease group (316.92±174.29) had no statistically significant difference. Conclusion The plasma D-dimer testing has some practical value for diagnosis and prognosis of newborns hypercoagulable state and thrombotic disease.

Key words: D-dimer, neonatal asphyxia, neonatal pneumonia, neonatal respiratory distress syndrome, neonatal jaundice

摘要： 目的分析新生儿常见疾病中早期血浆D-二聚体的水平并探讨其临床意义。方法常见新生儿疾病300例(实验组),健康新生儿50例(对照组),采集静脉血并检测D-二聚体含量。结果新生儿轻度窒息组D-二聚体的水平(1 167.5±683.7)及重度窒息组D-二聚体的水平(5 399.5±3 123.3)与健康对照组(320.4±145.5)相比均明显升高,其中重度窒息组D-二聚体水平升高更加显著。新生儿感染性肺炎组D-二聚体的水平(2 406.8±1 559.5)与显著高于健康对照组(320.4±145.5),差异有统计学意义。新生儿呼吸窘迫综合征(NRDS)组D-二聚体的水平( 1 975.6±1 205.6)与健康对照组(320.4±145.5)相比明显升高。新生儿病理性黄疸组(401.1±229.1)与对照组(320.4±145.5)相比差异具有统计学意义,新生儿湿肺D-二聚体的水平(316.9±174.2)与对照组(320.4±145.5)相比差异无统计学意义。结论血浆D-二聚体的检测对新生儿可能发生高凝状态和血栓性疾病的诊断及预后判断有一定实用价值。

关键词: D-二聚体, 新生儿窒息, 新生儿感染性肺炎, 新生儿呼吸窘迫综合征, 新生儿病理性黄疸

CLC Number:

R179

FU Shu-fang,XU Zhi-liang. Detection and significance of plasma D-dimer in early neonatal common diseases[J]. journal1, 2017, 25(2): 180-182.

付淑芳,徐之良. 新生儿常见疾病早期血浆D-二聚体的检测及意义[J]. 中国儿童保健杂志, 2017, 25(2): 180-182.

0
/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://manu41.magtech.com.cn/Jwk_zgetbjzz/EN/10.11852/zgetbjzz2017-25-02-21

https://manu41.magtech.com.cn/Jwk_zgetbjzz/EN/Y2017/V25/I2/180

References

[1] Folsom AR,Alonso A,George KM,et al.Prospective study of plasma D-dimer and incident venous thromboembolism:The atherosclerosis risk in communities (ARIC) study[J].Thromb Res,2015,136(4):781-785.
[2] Olson JD.D-dimer:An overview of hemostasis and fibrinolysis,assays,and clinical applications[J].Adv Clin Chem,2015,69(2):1-46.
[3] Legnani C,Cini M,Frascaro M,et al.Diagnostic accuracy of a new d-dimer assay (sclavo auto d-dimer) for exclusion of deep vein thrombosis in symptomatic outpatients[J].Clin Appl Thromb Hemost,2016,18(3):126-129.
[4] Van Es N,van der Hulle T,van Es J,et al.Wells rule and d-Dimer testing to rule out pulmonary embolism:a systematic review and individual-patient data meta-analysis[J].Ann Intern Med,2016,17(2):145-149.
[5] Alexander M,Wolfe R,Ball D,et al.OC-05-D-Dimer,fibrinogen and TEG-MA predict thromboembolism in non-small cell lung cancer-interim results from a prospective cohort study[J].Thromb Res,2016,140(1):170-173.
[6] Hedengran KK,Andersen MR,Stender S,et al.Large D-dimer fluctuation in normal pregnancy:a longitudinal cohort study of 4,117 samples from 714 healthy danish women[J].Obstet Gynecol Int,2016,20(16):561-675.
[7] Kowalski J,Jdrzejczyk JT,Barylski M,et al.Value of D-dimer and HDL cholesterol concentrations in predicting the occurrence of acute pulmonary embolism[J].Pol Merkur Lekarski,2016,40(239):283-287.
[8] Bi XW,Wang L,Zhang WW,et al.High pretreatment D-Dimer levels correlate with adverse clinical features and predict poor survival in patients with natural killer/T-Cell lymphoma[J].PLoS One,2016,11(3):842-845.
[9] 高岭,韩军,程成,等.小儿支原体肺炎合并胸腔积液体内D-二聚体、降钙素原、C-反应蛋白变化研究[J].中国儿童保健杂志,2016,24(2):185-189.
[10] 胡亚美,江载芳,申昆玲,等.诸福棠实用儿科学[M].8版.北京:人民卫生出版社,2015:450-483.
[11] 李玮,王缚鲲,安黎云.D-二聚体检测方法及临床应用进展[J].解放军医药杂志,2013,5(25):80-83.
[12] 王迎彬,胡金红,黄秀峰,等.D-二聚体在血栓性疾病中的诊断价值研究进展[J].解剖学研究,2015,5(37):429-431.
[13] Wolberg AS,Rosendaal FR,Weitz JI.Venous thrombosis[J].Nat Rev Dis Primers,2015,7(1):150-156.
[14] Liu P,Wang Y,Tong L,et al.Elevated preoperative plasma D-dimer level is a useful predictor of chemoresistance and poor disease outcome for serous ovarian cancer patients[J].Cancer Chemother Pharmacol,2015,76(6):1163-1171.
[15] Wada H.Pre-thrombotic (Hypercoagulable) state/Hypercoagulable disease[J].Rinsho Byori,2015,63(12):1405-1411.
[16] Ke L,Ni HB,Tong ZH.,et al.D-dimer as a marker of severity in patients with severe acute pancreatitis[J].J Hepatobiliary Pancreat Sci,2012,19(3):259-265.
[17] Couturaud F.Guided duration of anticoagulation after unprovoked venous thromboembolism using D-dimer testing[J].Eur Respir J,2016,47(5):1313-1314.