Abstract: Objective To analyse the influence of long-term oral use of glucocorticoid on mood and mental state of children with chronic disease.Method Totally 140 children with chronic illness aged from 10 to 18 were selected by convenience sampling to finish the self-designed questionnaire,Piers-Harris Children's Self-concept Scale(PHCSS) and Depression Self-Rating Scale for Children (DSRSC).Multiple hierarchical regression analysis was used to explore the effect of extended oral glucocorticoid on mood and mental state of participants.Results The average score of self-concept scale and depression scale were 55.50±11.49 and 9.11±4.81 respectively.29.0%children reported low level of self-concept(<50 scores)and 15.9% children were with high level of depression.The results of hierarchical regression analysis showed that the long-term oral use of glucocorticoid could explain 5.6% of the variance in self-concept and 3.1% in depression.Conclusion Long-term oral use of glucocorticoid could influence the mood and mental state of children with chronic disease,who are prone to appear low level of self-evaluation and depression disorder.

Key words: long-term, glucocorticoid, self-concept, depression, pediatric patients

摘要： 目的 分析长期口服糖皮质激素对慢性病患儿情绪心理状态的影响。方法 采用便利抽样方法,选取口服糖皮质激素类药物3个月及以上的10~18岁患儿140例,采用Piers-Harris儿童自我意识量表及儿童抑郁障碍自评量表等进行调查,运用分层回归分析方法探讨长期口服糖皮质激素对患儿情绪心理状态的影响。结果 本研究中138名慢性病患儿自我意识得分为55.50±11.49,29.0%的患儿自我意识水平较低;抑郁障碍自评量表得分为9.11±4.81,15.9%的患儿存在抑郁障碍。分层回归分析结果显示,激素用药状况可分别解释自我意识、抑郁障碍5.6%、3.1%的变异量。结论 长期口服糖皮质激素会影响慢性病患儿的情绪心理状态,易出现自我评价较低、抑郁障碍等负性情绪反应,应予以关注。

关键词: 长期, 糖皮质激素, 自我意识, 抑郁, 患儿