Dynamic monitoring of platelet during bronchopulmonary dysplasia in premature infants

doi:10.11852/zgetbjzz2018-0774

Abstract

Abstract: Objective To investigate the relationship between platelet and preterm infant with bronchopulmonary dysplasia(BPD). Methods Data of premature infants with gestational age less than 32 weeks,and living more than 28 days in Beijing Friendship Hospital were retrospectively analyzed from January 2013 to April 2017.Children were classified into case group and control group according to the BPD diagnosis.The mean values of four indexes of platelet during hospitalization,including platelet count (PLT),platelet width (PDW),mean platelet volume (MPV) and platelet count (PCT),and those at ≤7 days,7＜-14 days and 14＜-21 days were analyzed. Results Totally 87 preterm infants met the inclusion criteria,and 79 cases were included in this study finally.There were 30 cases in BPD group (case group) and 49 cases in non-BPD group (control group).The gestational age and birth weight in case group were significantly lower than those in control group(P＜0.001).The levels of PLT and PCT in case group were significantly decreased compared with control group (P=0.008,0.003).And the level of MPV in case group significantly lower than that in control group in 7 days after birth (P＜0.001). Conclusion The formation and development of pulmonary micro vessels play an important role in the development of BPD,and platelets may be the key role in this process of BPD.

Key words: bronchopulmonary dysplasia, pathogenesis, pathogenic mechanism, premature infants

摘要： 目的探讨血小板与早产儿支气管肺发育不良(BPD)之间的关系。方法应用回顾性病例对照研究,对2013年1月-2017年4月首都医科大学附属北京友谊医院收治的出生胎龄≤32周并存活28 d以上的早产儿临床资料和血小板四项进行统计和分析。病例组为根据BPD诊断标准诊断BPD的早产儿,对照组为非BPD的早产儿。分别对住院期间血小板计数(PLT)、血小板分布宽度(PDW)、平均血小板体积(MPV)、血小板压积(PCT)的平均值及住院≤7 d、7<~14 d和14<~ 21 d血小板四项平均值进行统计。结果本研究中≤32周并存活28 d以上的早产儿共有87例,最终纳入研究的患儿79例,30例BPD患儿为病例组,49例非BPD患儿为对照组。病例组胎龄及出生体重均较对照组患儿显著减低。病例组与对照组住院期间血小板四项平均值进行比较,病例组血小板计数(PLT)及血小板压积(PCT)的平均值较对照组显著减低(P=0.008、0.003)。病例组与对照组生后7 d内血小板四项平均值进行比较,病例组平均血小板体积(MPV)较对照组显著减小(P<0.001)。结论早产儿肺部微血管的形成及发育在BPD的发生方面发挥重要作用,而血小板可能在此过程中扮演重要角色。

关键词: 支气管肺发育不良, 血小板, 发病机制, 早产儿

CLC Number:

R722.6

FU Pei-pei, XIE Meng, CUI Hong. Dynamic monitoring of platelet during bronchopulmonary dysplasia in premature infants[J]. journal1, 2019, 27(6): 656-658.

付培培, 谢萌, 崔红. 早产儿支气管肺发育不良形成过程中血小板动态监测[J]. 中国儿童保健杂志, 2019, 27(6): 656-658.

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