journal1 ›› 2019, Vol. 27 ›› Issue (2): 171-174.DOI: 10.11852/zgetbjzz2018-0998

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Predictive value of cord blood markers in neonatal early-onset sepsis


  1. Department of Pediatrics, Lanzhou University Second Hospital, Lanzhou, Gansu 730030,China
  • Received:2018-07-26 Revised:2018-09-25 Online:2019-02-20 Published:2019-02-20
  • Contact: XU Ding,



  1. 兰州大学第二医院儿科,甘肃 兰州 730030
  • 通讯作者: 徐丁,
  • 作者简介:李艳萍(1992-),女,山东人,在读硕士,主要研究方向为新生儿败血症

Abstract: Neonatal mortality has become one of the important indicators for measuring the level of health development in a country.Because of the low immunity, newborns are prone to developing various infectious diseases after birth, and the infection is difficult to control.Early detection, as well as timely and rational use of antibiotics to treat infections have become an urgent problem to be solved.This review describes the predictive value of C-reactive protein, procalcitonin, interleukin 6, and hepcidin in cord blood for early-onset sepsis in neonates, and illustrates the action and mechanism of various factors, as well as the interaction of maternity, placenta and fetus.

Key words: neonates, early-onset sepsis, hepcidin, C-reactive protein, procalcitonin, interleukin 6

摘要: 新生儿死亡率已成为衡量一个国家卫生发展水平的重要指标之一。新生儿因其免疫力低下,出生后易发生各种感染性疾病,且感染不易控制。早期发现并及时合理使用抗生素治疗感染已成为亟待解决的问题。本综述介绍了在脐血中检测到的C反应蛋白、降钙素原、白介素6、铁调素等对新生儿早发型败血症的预测价值,并研究了各因子产生及作用机理,母体、胎盘与胎儿之间的互相作用。

关键词: 新生儿, 早发型败血症, 铁调素, C反应蛋白, 降钙素原, 白介素6

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