Possible mechanism of vitamin A deficiency causing anemia in children

doi:10.11852/zgetbjzz2019-0825

Abstract

Abstract: Vitamin A(VA) deficiency and anemia in children are worldwide public health problems.Lack of VA will not only cause serious eye diseases in children,but also lead to the occurrence and development of many diseases in children′s respiratory system,immune system,digestive system,blood system,reproductive system and other systems.Anemia also has impact on children′s growth,immune function,learning ability and other aspects.Many studies have confirmed that the deficiency of VA can cause anemia in children,but there is no unified explanation for the specific mechanism.This review summarizes the etiology and mechanism of anemia caused by VA in children.

Key words: anemia, vitamin A, erythropoietin, hepcidin

摘要： 小儿维生素A(VA)缺乏和贫血都是世界公共卫生问题。由于VA 缺乏不仅会引起小儿严重眼部疾病,还可导致小儿呼吸系统、免疫系统、消化系统、血液系统、生殖系统等多个系统多种疾病的发生发展;贫血对儿童的生长发育、免疫功能、学习能力等方面也有着重要影响。许多研究已证实VA缺乏可导致小儿贫血,但具体的机制目前尚无统一说法。以下就VA引起小儿贫血的病因机制做一综述。

关键词: 贫血, 维生素A, 促红细胞生成素, 铁调素

CLC Number:

R725.5

WANG Qin, ZHAO Lin. Possible mechanism of vitamin A deficiency causing anemia in children[J]. journal1, 2020, 28(6): 657-659.

王琴, 赵琳. 维生素A缺乏致小儿贫血的可能机制[J]. 中国儿童保健杂志, 2020, 28(6): 657-659.

References

[1] Nambiema A,Robert A,Yaya I.Prevalence and risk factors of anemia in children aged from 6 to 59 months in Togo:analysis from Togo demographic and health survey data,2013-2014[J].BMC Public Health,2019,19(1):215.
[2] Özdemir N.Iron deficiency anemia from diagnosis to treatm ent in children[J].Turk Pediatri Ars,2015,50(1):11-19.
[3] Abolurin O,Adegbola A,Oyelami O,et al.Vitamin A deficiency among under-five Nigerian children with diarrhoea[J].Afr Health Sci,2018,18(3):737-742.
[4] Chiu M,Dillon A,Watson S.Vitamin A deficiency and xerophthalmia in children of a developed country[J].J Paediatr Child Health,2016,52(7):699-703.
[5] Chaudhry AB,Hajat S,Rizkallah N,et al.Risk factors for vitamin A and D deficiencies among children under-five in the state of Palestine[J].Confl Health,2018,12:13.
[6] Cabezas-Wallscheid N,Buettner F,Sommerkamp P,et al.Vitamin A-retinoic acid signaling regulates hematopoietic stem cell dormancy[J].Cell,2017,169(5):807-823.
[7] 贺景颐.维生素A缺乏对贫血的影响及机制研究进展[D].重庆:重庆医科大学,2013.
[8] Niu H,Fujiwara H,di Martino O,et al.Endogenous retinoid X receptor ligands in mouse hematopoietic cells[J].Sci Signal,2017,10(503):1011.
[9] de Lera Á,Krezel W,Rühl R.An endogenous mammalian retinoid X peceptor ligand,at last[J].Chem Med Chem,2016,11(10):1027-1037.
[10] Hibler E,Jurutka P,Egan J,et al.Gestational vitamin D supplementation leads to reduced perinatal RXRA DNA methylation:Results from the MAVIDOS trial[J].J Bone Miner Res,2018,34(2):231-240.
[11] Mendes JF,Siqueira EM,de Brito E Silva JG,et al.Vitamin A deficiency modulates iron metabolism independent of hemojuvelin(Hfe2)and bone morphogenetic protein 6 (Bmp6) transcript levels[J].Genes Nutr,2016,11:1.
[12] Houston D.Hepcidin and the anemia of critical illness[J].Crit Care Med,2018,46(6):1030-1031.
[13] van Vuren AJ,Gaillard CAJ M,Eisenga MF,et al.The EPO-FGF23 signaling pathway in erythroid progenitor cells:opening a new area of research[J].Front Physiol,2019,10:304.
[14] Matsuyama T,Tanaka T,Tatsumi K,et al.Midazolam inhibits the hypoxia-induced up-regulation of erythropoietin in the central nervous system[J].Eur J Pharmacol,2015,761:189-198.
[15] Zhang Y,Zhang Y,Gu W,et al.Th1/Th2 cell′s function in immune system[J].Adv Exp Med Biol,2014:45-65.
[16] Spinas E,Saggini A,Kritas SK,et al.Can vitamin a mediate immunity and inflammation?[J].J Biol Regul Homeost Agents,2015,29(1):1-6.
[17] Wang C,Babitt J.Hepcidin regulation in the anemia of inflammation[J].Curr Opin Hematol,2016,23(3):189-197.
[18] Albayrak C,Tarkun P,Birtaş Ateşoĝlu E,et al.The role of hepcidin,GDF15,and mitoferrin-1 in iron metabolism of polycythemia vera and essential thrombocytosis patients[J].Turk J Med Sci,2019,49(1):74-80.
[19] Li L,Zhang J,Zhao M,et al.Applied value of monitoring serum hepcidin in differential diagnosis of infection versus tumor fevers[J].J Huazhong Univ Sci Technolog Med Sci,2017,37(2):253-256.
[20] Cui Q,Chen F,Zhang M,et al.Transcriptomic analysis revealing hepcidin expression in Oryzias melastigma regulated through the JAK-STAT signaling pathway upon exposure to BaP[J].Aquat Toxicol,2019,206:134-141.
[21] Larson L,Guo J,Williams A,et al.Approaches to assess vitamin A status in settings of inflammation:biomarkers reflecting inflammation and nutritional determinants of anemia (BRINDA) project[J].Nutrients,2018,10(8):1100.