Abstract: Objective To study the clinical efficacy of low dose iron supplementation on prevention of premature infant anemia. Methods A total of 68 premature infants were randomly selected as research objects from the follow-up center of high-risk infants in Nanjing Maternal and Child Health Hospital. The research group was treated with low dose of iron according to the feeding pattern of the premature infants. The breast-fed infants were supplied with oral elemental iron 2 mg/kg per day and the artificial feeding infants were supplied with oral elemental iron 1 mg/kg per day. The iron dosage of mixed-fed infants were chosen according to the proportion of formula of total milk amount(<50%,2 mg/kg;≥50%,1.5 mg/kg). Over the same period,another 72 premature infants who did not participate in follow up were chosen as control group without oral supplement of iron. The routine blood was tested when the premature infants were six months old. Results The average hemoglobin level of intervention group was higher than that of the control group (P<0.05) and the incidence of anemia in intervention group was significantly lower than that in control group (P<0.05). In addition,no significant differences on the incidence of anemia were found among infants with different feeding-pattern in intervention group. Conclusions Low dose iron supplementation based on feeding patterns can effectively improve the levels of iron storage and reduce the prevalence of anemia in premature infants.

Key words: premature infants, iron, anemia, prevention

摘要： 目的 分析小剂量补铁预防早产儿贫血的临床疗效,为儿童保健工作中合理使用铁剂预防早产儿贫血提供参考依据。方法 选取南京市妇幼保健院高危儿随访中心进行随访的早产儿68例作为干预组,根据喂养方式给予小剂量铁剂口服,母乳喂养者铁元素每日2 mg/kg,人工喂养者每日铁元素1 mg/kg,混合喂养者按配方奶占总奶量的比例:<50%,每日铁元素2 mg/kg;≥50%,每日铁元素1.5 mg/kg。同期选择未参加高危儿随访并且未补充铁剂的72名早产儿为对照组,两组早产儿均在生后6月龄检测血常规。结果 干预组的血红蛋白平均值明显高于对照组 (P<0.05);干预组贫血的发生率较对照组显著降低(P<0.05);干预组不同喂养方式之间比较贫血的发生率无显著差别。结论 基于喂养方式的小剂量补铁,能有效增加早产儿体内铁储备,降低早产儿贫血的发生率。

关键词: 早产儿, 铁, 贫血, 预防